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Primary small-cell carcinoma of the endometrium: Clinicopathological study of a case and review of the literature

  • M. Varras1,*,
  • Ch. Akrivis1
  • A. Demou2
  • G. Hadjopoulos1
  • S. Stefanaki2
  • N. Antoniou1

1Department of Obstetrics and Gynaecology, Greece

2Department of Pathology, "G. Chatzikosta" - General State Hospital, Ioannina, Greece

DOI: 10.12892/ejgo200206577 Vol.23,Issue 6,November 2002 pp.577-581

Published: 10 November 2002

*Corresponding Author(s): M. Varras E-mail:

Abstract

Background: Small-cell carcinomas are almost always primary in the lungs and are highly malignant. These tumors may also occur in the female genital tract. However, primary small-cell carcinoma of the endometrium is extremely rare with very few cases reported in the English literature. This tumor may exhibit evidence of neuroendocrine differentiation and has a high propensity for systemic spread and poor prognosis.

Case: A 55-year-old postmenopausal woman with primary small-cell carcinoma of the endometrium, FIGO stage Ib, underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy and sampling node biopsies of the parametrial spaces, followed by adjuvant combined chemotherapy.

Conclusion: A case of small-cell carcinoma of the endometrium, is reported and its clinical, histological and immunohistochemical features are discussed.

Keywords

Small cell; Neuroendocrine; Carcinoma; Endometrial neoplasms

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M. Varras,Ch. Akrivis,A. Demou,G. Hadjopoulos,S. Stefanaki,N. Antoniou. Primary small-cell carcinoma of the endometrium: Clinicopathological study of a case and review of the literature. European Journal of Gynaecological Oncology. 2002. 23(6);577-581.

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