Article Data

  • Views 329
  • Dowloads 136

Original Research

Open Access

Ultra short-term antimicrobial prophylaxis in patients undergoing surgery for gynecologic cancer

  • G. Cormio1,*,
  • F. Di Fazio1
  • G. Di Gesu1
  • M. Scioscia1
  • C. Carriero1
  • G. Loverro1
  • L. Selvaggi1

1Section A - Gynecology and Obstetrics Department()f General and Specialized Surgery, University of Bari, Italy

DOI: 10.12892/ejgo20030163 Vol.24,Issue 1,January 2003 pp.63-66

Published: 10 January 2003

*Corresponding Author(s): G. Cormio E-mail:

Abstract

Objective: To evaluate the efficacy of ultra short-term antimicrobial prophylaxis with ceftazidime in patients undergoing radical gynecologic surgery.

Patients and methods: Two hundred patients undergoing surgery for a malignant disease of the female genital tract were enrolled in a prospective trial to receive 2.0 g ceftazidime as a single dose, 30 minutes before induction of anaesthesia. After surgery, each patient was assessed to confirm febrile status and the presence of infections at the surgical site, urinary tract and respiratory tract.

Results: Postoperative morbidity occurred in 23 patients (11, 5%). Ten patients (5%) developed febrile morbidity, five (2, 5%) vaginal cuff infections, four asymptomatic bacteriuria and two each wound infiltration and urinary tract infection. Twelve patients had microbiological evidence of infection and Staphylococccus aureus was the most common pathogen isolated. Univariate analysis demonstrated that pre-existing systemic disease, extensive blood loss (more than 500 ml) and long duration of surgery (more than 150 minutes) were the only factors associated with a significant increase in postoperative febrile morbidity.

Conclusions: Ultra short-term antimicrobial prophylaxis with ceftazidime is safe and effective in patients undergoing surgery for gynecologic cancer.

Keywords

Radical gynecologic surgery; Antimicrobial prophylaxis; Ceftazidime

Cite and Share

G. Cormio,F. Di Fazio,G. Di Gesu,M. Scioscia,C. Carriero,G. Loverro,L. Selvaggi. Ultra short-term antimicrobial prophylaxis in patients undergoing surgery for gynecologic cancer . European Journal of Gynaecological Oncology. 2003. 24(1);63-66.

References

[1] Hirsch H. A.: "Post-operative infections". In "Surgical Gynecological Oncology", E. Burghardt (ed.) Stuttgard, George Thieme Verlag, 1993.

[2] Crombleholme W. R.: "Use of prophylactic antibiotics in obstetrics and gynecology". Clin. Obstet. Gynecol., 1988, 31, 466.

[3] Marsden D. E., Cavanagh D., Wisniewski B. J., Roberts W. S., Lyman G. H.: "Factors affecting the incidence of infectious morbiidity after radical hysterectomy". Am. J. Obstet. Gynecol., 1985, 152, 817.

[4] Page C. P., Bohnen J. M. A., Fletcher J. R., McMAnus A. T., Solomkin J. S., Wittman D. H.: "Antimicrobial prophylaxis for surgical wound. Guidelines for clinical care". Arch. Surg., 1993, 128, 79.

[5] Mayer H. O., Petru E., Haas J., Heydarfadai M.: "Perioperative antibiotic prophylaxis in patients undergoing radical surgery for gynecologic cancer: single versus multiple dose administration" Eur. J. Gynecol. Oncol., 1993, 14, 177.

[6] Orr J. W., Sisson P. F., Patsner B. et al.: "Single dose antibiotic prophylaxis for patients undergoing extended pelvic surgery for gynecologic malignancy". Arn. J. Obstet. Gynecol., 1990, 162, 718.

[7] Sevin B. U., Ramos R., Lichtinger M., Girtanner, Averette H. E.: "Antibiotic prevention of infectious complicating radical abdominal hysterectomy". Obstet. Gynecol., 1984, 64, 539.

[8] Patsner B.: "Closed-suction drainage versus no drainage following radical abdominal hysterectomy with pelvic lymphadenectomy for stage lb cervical cancer". Gynecol. Oneal., 1995, 57, 232.

[9] Heintz A. P. M., Hacker N. F., Berek J. S., Rose T. P., Munoz A K., Lagasse L. D.: "Cytoreductive surgery in ovarian carcinoma: feasibility and morb心ty". Obstet. Gynecol., 1986, 67, 783.

[10] Wilson A. P., Weavil! C., Burridge J., Kelsey M. C.: "The use of the wound scoring method "ASEPSIS" in postoperative wound surveillance". J. Hosp. Infect., 1990, 16 (4), 297.

[11] Richards D. M., Brogden R. N.: "Ceftazidime: a review of its antibacterial activities and pharmacokinetic properties and therapeutic use". Drugs, 1985, 29, 105.

[12] Lomeo A. M., Glambersio A. M., Iacobellis G.: "Ceftazidimem the prevention of post-operative infections in gynecological surgery". Clin. Trials. J., 1990, 27 (4), 278.

[13] Colombo M., Zanetta G., Negri L., Scalambrino S., Pasta F., Arreghini A.: "A randomized comparison of one dose versus two doses antibiotic prophylaxis in gynecologic surgery lasting over two hours". Int. J. Obstet. Gynecol., 1998, 1, 9.

[14] McDonald P. J., O'Loughlin J. A.: "Prophylactic antibiotics and prevention of surgical sepsis". Baill. Clin. Obstet. Gynaecol., 1993, 7 (1), 219.

[15] Ledger W. J.: "Guidelines for choosing prophylactic antibiotics" Conternp. Obstet. Gynecol., 1990, 35, 27.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top