Cancer of the cervix with endometrial extension treated by radiotherapy: A retrospective case-control study

Background: Studies determining prognosis of cancer of the cervix with endometrial extension (CCEE) in a case-control fashion are scant.

Methods: A case-control retrospective study of 20 women with CCEE and 16 patients with cervical cancer not extending to the endometrium (CCNEE) treated by radiation was undertaken. The patient groups were matched for age, disease stage, the presence of bulky/barrel-shaped tumor in the cervix, intercurrent illness, total radiation dose, and hemoglobin level. The overall mean follow-up was 54 months (range 8 to 218 months).

Results: The numerical rates of local and systemic failure as well as 5-year survival were worse for patients with CCEE versus CCNEE. However, the observed differences were not statistically significant.

Conclusion: Involvement of the endometrium by cancer of the cervix seems to confer a worse outcome among cervical cancer patients treated by radiation alone.

Cancer of the cervix; Endometrial extension; Radiotherapy

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