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Long-lasting complete remission of a patient with cervical cancer FIGO IVB treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin and consolidation chemotherapy—a case report
1Center of Oncology, Clinical Hospital, Split, Croatia
2Baxter Oncology GmbH, Frankfurt, Germany
*Corresponding Author(s): E. Vrdoljak E-mail:
The treatment of women with already metastasized cervical cancer at initial diagnosis represents a challenge to gynecologic oncologists. We report on a 63-year-old patient with locally advanced squamous cell carcinoma of the cervix uteri with an isolated metastasis to the left ovary. Following treatment with concomitant chemoradiotherapy with ifosfamide and cisplatin and three cycles of consolidation chemotherapy with the same drug combination a complete clinical remission could be documented. At present, 35 months after her disease was diagnosed, she is still without any evidence of disease. The very promising outcome of this patient might suggest that combined chemoradiation which is the standard treatment of locally advanced cervical cancer is justified as well in the metastatic setting, provided the metastatic lesion is covered within the usual radiation field.
Metastasized cervical cancer at initial diagnosis; Concomitant chemoradiation; Ifosfamide; Cisplatin; Consolidation chemotherapy
E. Vrdoljak,W. Hamm,T. Omrcen,T. Prskalo. Long-lasting complete remission of a patient with cervical cancer FIGO IVB treated by concomitant chemobrachyradiotherapy with ifosfamide and cisplatin and consolidation chemotherapy—a case report. European Journal of Gynaecological Oncology. 2004. 25(2);247-249.
[1] National Cancer Institute: NCI Clinical Announcement. Bethesda, MD, United States Department of Health and Human Services, Public Health Service, National Institutes of Health, February 1999.
[2] Omura G.A., Blessing J.A., Vaccarello L., Bermen M.L., ClarkePearson D.L., Mutch D.L., Anderson B.: "Randomized trial of cisplatin versus cisplatin plus mitolactol versus cisplatin plus ifosfamide in advanced squamous carcinoma of the cervix: a Gynecologic Oncology Group study". J. Clin. Oncol., 1997, 15, 165.
[3] De Jonge E.T.M., Falkson G., Burger W.: "Neoadjuvant cisplatin and ifosfamide in patients with Stage JIB cervical cancer: a single center phase II study". Int. J. Gynecol. Cancer, 1997, 7, 158.
[4] Vermorken J.B.: "The role of chemotherapy in squamous cell carcinoma of the uterine cervix. A review". Int. J. Gynecol. Cancer, 1993, 3, 129.
[5] Thigpen T., Vance R., Khansur T., Malamud F.: "The role of ifosfamide and systemic therapy in the management of carcinoma of the cervix". Semin. Oncol., 1996, 6, 56.
[6] Tonkin K.S., Kelland L.R., Steel G.G.: "Chemotherapy-radiation interactions in human cervix carcinoma xenografts". Br. J. Cancer , 1988, 58, 738.
[7] Green J.A., Kirwan J.M., T ierney J.F., Symonds P., Fresco L., Collingwood M., W illiams CJ.: "Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and meta-analysis". Lancet, 2001,358, 781.
[8] Peters W.A. III, L iu P.Y., Barrett R.J., Stock R.J., Monk B.J., Berek J.S. et al.: "Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix". J. Clin. Oncol., 2000, 18, 1606.
[9] V rdoljak E., Prskalo T., Frleta Ilic N., Hamm W.: "Concomitant chemobrachyradiotherapy with ifosfamide and cisplatin followed by consolidation chemotherapy in locally advanced squamous cell carcinoma (LASCC) of the cervix uteri: results of a phase II study" (abstr. 79). Gynecol. Oncol., 2003, 88, 194.
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