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Failure of imaging techniques in revealing breast cancer progression
1Department of Clinical Medicine, Oncology Unit, University of Rome "La Sapienza" , Italy
2Division of General Surgery, "Policlinico Casilino" Hospital, Rome, Italy
*Corresponding Author(s): F. FRANCHI E-mail:
This study focuses on a case of a 67-year-old woman with occult breast cancer involving the axillary lymph nodes. The instrumental examinations employed, positron emission tomography included, were not useful in diagnosing the disease. When the patient was surgically treated micro-invasive breast cancer was diagnosed. This peculiar malignant pathology is a matter of discussion especially because it is hardly diagnosable. Because of such diagnostic difficulties it may happen that micro-invasive carcinoma progression can easily mislead routine diagnostic screenings performed on women over 50.
Breast cancer; Micro-invasive breast carcinoma; Early diagnosis; Imaging techniques
F. FRANCHI,T. Ielapi,L. Gargano,G. Pasciuti,G. Nigita,P. Seminara. Failure of imaging techniques in revealing breast cancer progression. European Journal of Gynaecological Oncology. 2004. 25(5);637-639.
[1] Halsted W.S.: "The result of radical operations for the cure of carcinoma of the breast". Ann. Surg., 1907, 46, 1.
[2] Silver S.A.,Tavassoli FA.:''Mammari ductal carcinoma in situ with microinvasion". Cancer, 1998, 82 (12), 2382.
[3] Schuh M.E., Nemoto T., Penetrante R.B. et al.: "Intraductal care!coma: analysis of presentation, pathologic findings, and outcome of disease". Arch. Surg., 1986, 121, 1303.
[4] Wong J.H., Kopald K.H., Morton D.L.: "The impact of m1croinvasion on axillary node metastases and survival in patient with intraductal breast cancer". Arch. Surg., 1990, 125, 1298.
[5] Silverstein M.J., Rosser R.J., Gierson E.D. et al.: "Axillary lymph node dissection for inraductal breast carcinoma: is it indicated'1". Cancer, 1987, 59, 1819.
[6] Silverstein M.J., Waisman J.R., Gamagami P. et al.: "Intraductal carcinoma of the breast (208 cases): clinical factors influencing treatment choice". Cancer, 1990, 66, 102.
[7] Howard P.W., Locker A.P., Dowle C.S. et al.: "In situ carcmoma of the breast". Eur. J. Surg. Oncol., 1989, 15, 328.
[8] Coyne J., Haboubi N.Y.: "Micro-invasive breast carcinoma with granulomatous stromal response". Histopathology, 1992, 20, 184.
[9] Harrison R.I., Glenn D.C., Niesche F.W. et al.: "Surgical management of breast cancer: experience of the central Sydney area healt service breast X-ray programme, 1988-1991". Med. J. Aust., 1994, 160, 617.
[10] Nevin J.E., Pinzon G., Moran T.J., Baggerly J.T.: "Minimal breast carcinoma". Am. J. Surg., 1980, 139, 357.
[11] Holland R., Veling S.H., Mravunac M., Hendriks J.H.: "Histologic multifocality of Tis, Tl-2 breast carcinomas: implications for clinical trials of breast-conserving surgery". Cancer, 1985, 56, 979.
[12] Gallager H.S., Martin J.E.: "An orientation to the concept of minimal breast cancer". Cancer, 1971, 28, 1505.
[13] Bedwani R., Vana J., Rosner D. et al.: "Management and survival of female patients with "minimal" breast cancer: as observed in the long-term and short-term surveys of the American College ot Surgeons". Cancer, 1981, 47, 2769.
[14] Jotti G.S., Petit G.Y., Contesso G.: "Minimal breasrcancer: a elmically meaningful term?". Semin. Oncol., 1986, 13, 384.
[15] Hoda R.S., Chiu A., Hoda S. A.: "Microinvasive carcinoma of breast". Arch. Pathol. Lab. Med., 2001, 125, 1259.
[16] Kyokane T., Akashi-Tanaka S., Matsui T., Fukutomi T.: "Chrncopathological characteristics of non-palpable breast cancer presenting as an axillary mass". Breast Cancer, 1995, 2, 105.
[17] Baron P.L., Moore M.P., Kinne D.W. et al.: "Occult breast cancer presenting with axillary metastases: updated management". Arch Surg., 1990, 125, 210.
[18] Kemeny M.M., Rivera D.E., Terz J.J., Benfield J.R.: "Occult primary adenocarcinoma with axillary metastases". Am. J. Surg., 1986, 152, 43.
[19] Patel J., Nemoto T., Rosner D. et al.: "Axillary lymph node metastases from an occult breast cancer". Cancer, 1981, 47, 2923.
[20] Kerlikowske K., Carney P.A., Geller B. et al.: "Performance of screening mammography among women with and without a firstdegree relative with breast cancer". Ann. Intern. Med., 2000, 133, 855.
[21] Kerlikowske K., Grady D., Barclay J. et al.: "Likelihood ratios for modern screening mammography. Risk of breast cancer based on age and mammographic interpretation". JAMA, 1996, 276, 39.
[22] Rosenberg R.D., Hunt W.C., Williamson M.R. et al.: "Effects of age, breast density, ethnicity and estrogen replacement therapy on screening mammographic sensitivity and cancer stage at diagnosis: review of 183,134 screening mammograms in Albuquerque, New Mexico". Radiology, 1998, 209, 511.
[23] Carney P.A., Miglioretti D.L., Yankaskas B.C. et al.: "Individual and combined effects of age, breast density and hqrmone replacement therapy use on the accuracy of screening mammography" Ann. Intern. Med., 2003, 138, 168.
[24] Mushlin A.I., Kouides R.W., Shapiro D.E.: "Estimating the accuracy of screening mammography: a meta analysis". Am. J. Prev Med., 1998, 14, 143.
[25] Reynolds H.E., Poon C.M., Goulet R.J., Lazridis C.L.: "Biopsy of breast microcalcifications using an I I-gauge directed vacuumassisted device". Am. J. Radiol., 1998, 171, 611.
[26] Lovin J.D., Parker S.H., Jobe W.E. et al.: "Stereotactic percutaneous breast core biopsy: technical adaptation and initial experience". Breast Dis., 1990, 3, 135.
[27J Parker S.H., Lovin J.D., Jobe W.E. et al.: "Stereotactic breast biopsy with a biopsy gun". Radiology, 1990, 176, 741.
[28] Tae-Seon K., Woo Kyung M., Dong-Soo L. et al.: "Fluorodeoxyglucose positron emission tomography for detection of recurrent or metastatic breast cancer". World J. Surg., 2001, 25, 829.
[29] Schwartz G.F., Patchefsky A.S., Finklestein S.D. et al.: "Nonpalpable in situ ductal carcinoma of the breast: predictors of multicentricity and microinvasion and implications for treatment" Arch. Surg., 1989, 124, 29.
[30] Solin L.J., Fowble B.L., Yeh I.-T., et al.: "Microinvasive ductal carcinoma of the breast treated with breast-conserving surgery and definitive irradiation". Int. J. Radial. Oncol. Biol. Phys., 1992, 23, 961.
[31] Patchefsky A.S., Schwartz G.F., Finkelstein S.D. et al.: "Heterogeneity of intraductal carcinoma of the breast". Cancer, I 989, 63, 731.
[32] Simpson T., Thirlby R.C., Dail D.H.: "Surgical treatment of ductal carcinoma in situ of the breast: JO- to 20-year follow-up". Arch Surg., 1992, 127, 468.
[33] Silverstein M.J., Gierson E.D., Colburn W.J. et al.: "Axillary lymphadenectomy for intraductal carcinoma of the breast''. Surg Gynecol. Obstet., 1991, 172, 211.
[34] Luparello C., Sirchia R., Pupello D.: "PTH2p [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression". J. Cell. Sci., 2003, 116, 2421.
[35] Duffy M.J.: "Urokynase - type plasminogen activator: a potent marker of metastatic potential in human cancer". Biochem. Soc. Trans., 2002, 30 (2), 207.
[36] Nordengren J., Fredstorp L.M., Bedahl P.O. et al.: "High tumor tissue concentration of plasmogen activator inhibitor 2 (PAI-2) is an indipendent marker for shorter progression free survival in patients with early stage endometrial cancer". Int. J. Cancer, 2002, 97 (3), 379.
[37] Duffy M.J.: "Urokynase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: from pilot to levelI evidence studies" (review). Clin. Chem., 2002, 48 (8), 1194
[38] Coradini D., Pellizzaro C., Veneroni S. et al.: "Infiltrating ductal and lobular breast carcinomas are characterised by different interrelationship among markers related to angiogenesis and hormone dependence". B1: J. Cancer, 2002, 87 (10), 1105.
[39] Achen M.J., Williams、R.A., Baldwin M.E. et al.: "The angiogenic and lymphangiogenic factor vascular endothelial growth factor-D exhibits a paracrin mode of action in cancer". Growth Factors, 2002, 20 (2), 99.
[40] Singh B., Lucci A.: "Role of cyclooxygenase-2 in breast cancer" J. Surg. Res., 2002, 108 (1), 173.
[41] Ozer E., Cauda T., Kurtodlu B.: "The role of angiogenesis, larrumn and CD44 expression in metastatic behaviour of early stage low grade invasive breast carcinomas". Cancer Lett., 1997, 121 (2), 119.
[42] Rochefort H., Garcia M., Glondu M. et al.: "Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview". Clinica Chirnica Acta, 2000, 291, 157.
[43] Jakson B., Scott-Conner C., Moulder J.: "Axillary metastasis from occult breast carcinoma: diagnosis and management". Arn. Surg., 1995, 61, 431.
[44] Van Ooijen B., Botenbal M., Henzen-Logmans S.C., Koper P.C.M.: "Axillary nodal metastases from an occult primary consistent with breast carcinoma". Br. J. Surg., 1993, 80, 1299.
[45] Ellertyoek N., Holmes F., Singletary E. et al.:'Treatment of patients with isolated axillary nodal metastases from occult primary carcinoma consistent with breast origin". Cancer, 1990, 66, 1461.
[46] Veronesi U., Salvadori B., Luini A. et al.: "Conservative treatment of early breast cancer: long-term results of 1232 cases treated with quadrantectomy, axillary dissection and radiotherapy". Ann. Surg., 1990, 211, 250.
[47] Vezzoni P., Balestrassi A., Bignami P. et al.: "Axillary limph node metastases from occult carcinoma of the breast". Turnori, 1979, 65, 87.
[48] Foroudi F., Tiver K.W.: "Occult breast carcinoma presentmg as axillary metastases". Int. J. Radial. Oncol. Biol. Phys., 2000, 47, 143.
[49] Giuliano A.E., Karrgan D.M., Guenther J.M., Morton D.L.: "Lymphatic mapping and sentinel lynphadenectomy for breast cancer" Ann. Surg., 1994, 220, 391 (Discussion, 398).
[50] O'Hea BJ., Hill A.D., El-Shirbiny A.M., Yeh S.D. et al.: "Sentinel lymph node biopsy in breast cancer: initial experience at Memorial Sloan-Kettering Cancer Center". J Arn. Coll. Surg., 1998, 186, 423.
[51] Adler L.P., Faulhaber P.F., Schnur K.C. et al.: "Axillary lymphnode metastases screening with [f-18] 2 - deoxy- 2- fluoro- Dglucose (FDG) PET". Radiology, 1997, 203, 323.
[52] Oshida M., Uno K., Suzuki M. et al.: Predicting prognoses of breast carcinoma patients with positron emission tomography using 2-deoxy-2-fluoro[18F]-D-glucose". Cancer, 1998, 82, 2227.
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