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Original Research

Open Access

ngenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines

  • A. Vigone1,*,
  • G.C. Tron1
  • D. Surico1
  • G. Baj1
  • G. Appendino2
  • N. Surico1

1Department of Obstetrics and Gynaecology, Italy

2Department of Pharmaceutical Technologies and Sciences, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy

DOI: 10.12892/ejgo200505526 Vol.26,Issue 5,September 2005 pp.526-530

Published: 10 September 2005

*Corresponding Author(s): A. Vigone E-mail:

Abstract

We present an analysis of the antitumour effects of a library of ingenol derivatives synthesized in our laboratory and published elsewhere. Fluoro-ingenol (1), ingenol-20-deoxy-20-phtalimido (2), ingenol-3-benzoate-20-deoxy-20-benzamide (3), ingenol-3-benzoate (4), ingenol-3,5-dibenzoate (5), ingenol-3,20-dibenzoate (6), 20-deoxy-20-benylureidoingenol-3-benzoate (7), ingenol-20-deoxy-20-fluoro-3-benzoate (8), ingenol-20-deoxy-20-fluoro-3,5-dibenzoate (9), ingenol-20-phenylcarbamate (10), ingenol-20-benzoate (11), ingenol-3-benzoate-20-phenylcarbamate (12) were tested in vitro on two well characterized breast cancer cell (BCC) lines, namely T47D and MDA-MB-231, as representative of two opposite types of hormone-sensitiveness and differentiation stage. These experiments led us to identify ingenol-20-benzoate (11) as a promising antitumour compound characterized by a relevant inhibition of cell growth and apoptotic cell death involving a p53-mediated pathway.

Keywords

Apoptosis; Breast cancer; Chemotherapy; Ingenol; PKC

Cite and Share

A. Vigone,G.C. Tron,D. Surico,G. Baj,G. Appendino,N. Surico. ngenol derivatives inhibit proliferation and induce apoptosis in breast cancer cell lines. European Journal of Gynaecological Oncology. 2005. 26(5);526-530.

References

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