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Original Research

Open Access

Efficiency of three surgical procedures in eliminating high­risk human papillomavirus infection in women with precancerous cervical lesions

  • N. Jancar1
  • S. Rakar1
  • M. Poljak2
  • K. Fujs2
  • B.J. Kocjan2
  • E. Vrtacnik-Bokal1,*,

1Department of Obstetrics and Gynecology, University Medical Centre Ljubljana, Ljubljana, Slovenia

2Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

DOI: 10.12892/ejgo200603239 Vol.27,Issue 3,May 2006 pp.239-242

Published: 10 May 2006

*Corresponding Author(s): E. Vrtacnik-Bokal E-mail:

Abstract

Purpose of investigation: To establish the efficiency of laser vaporization (LV), large loop excision of the transformation zone (LLETZ) and cold knife conization, done for precancerous cervical lesions, in eliminating high-risk human papillomavirus (HPV) infection. Additionally, we determined whether the same HPV genotype persisted after surgery.

Methods: A total of 214 women were tested for HPV infection by the Hybrid Capture II (HCII) test prior to surgery. HPV-positive women were followed by HCII test ten months after surgery. In persistently HPV-positive women, HPV genotypes were determined by PCR - PGMY09/PGMY11.

Results: The HCII test showed elimination of HPV infection after LV, LLETZ and cold knife conization in 67.6%, 86.3%, and 100% (p < 0.05) of women, respectively. In seven (38.9%) women a different HPV genotype was found to be present after surgery, the corrected efficiency thus being 79.4%, 92.7% and 100% (p = NS), respectively.

Conclusions: The three analyzed surgical procedures are effective in eliminating high-risk HPV infection. HPV testing is useful at follow-up, since it can identify a small proportion of women requiring close surveillance and potential treatment.

Keywords

Human papillomavirus; Precancerous cervical lesions; Surgical treatment; Follow-up

Cite and Share

N. Jancar,S. Rakar,M. Poljak,K. Fujs,B.J. Kocjan,E. Vrtacnik-Bokal. Efficiency of three surgical procedures in eliminating high­risk human papillomavirus infection in women with precancerous cervical lesions. European Journal of Gynaecological Oncology. 2006. 27(3);239-242.

References

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