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Original Research

Open Access

Prognostic significance of f ascin expression in endometrioid carcinoma

  • S. Kabukcuoglu1,*,
  • V. Oner1
  • S.S. Ozalp2
  • E. Dundar1
  • O.T. Yalcin2
  • E. Colak3

1Departments of Pathology, University of Osmangazi School of Medicine, Eskisehir, Turkey

2Departments of Gynecology and Obstetrics,University of Osmangazi School of Medicine, Eskisehir, Turkey

3Departments of Biostatistics, University of Osmangazi School of Medicine, Eskisehir, Turkey

DOI: 10.12892/ejgo200605481 Vol.27,Issue 5,September 2006 pp.481-486

Published: 10 September 2006

*Corresponding Author(s): S. Kabukcuoglu E-mail:

Abstract

Purpose of investigation: Actin bundling protein fascin has been previously associated with tumor progression in human cancers. We evaluated whether fascin also plays a role in endometrioid carcinomas.

Methods: Cases of 28 proliferative and hyperplastic endometrium and 43 endometrioid carcinomas were examined by immunohistochemistry using antihuman fascin antibody.

Results: Weak fascin expression in glandular epithelium was observed in 39% of non-neoplastic samples and various degrees of fascin expression were observed in 74% of neoplastic samples. The number of positively stained samples and intensity of epithelial staining were significantly higher in endometrioid carcinoma compared to the non-neoplastic group (p < 0.001). The number of posilively stained samples and total fascin scores of stroma were significantly higher in proliferative and hyperplastic endometrium biopsies compared to the endometrioid carcinoma (p < 0.001). Higher grade endometrioid carcinoma cases had significantly increased total epithelial fascin scores (.042, p < 0.05). There was also a significant difference between tumor grade and patient survival (.040, p <0.05). There was a significant correlation between microvessel count and disease-free survival (r =.412, p = .006). In the proliferative and hyperplastic endometrial biopsies microvessels stained homogeneously in all cases (28/28), but in the endometrioid carcinoma group eight out of 43 cases showed heterogeneous fascin staining of microvessels. The difference was significant (.019, p < 0.05).

Conclusions: Our study supported the dynamic role of actin bundling protein fascin in generating and maintaining endometrial neoplasms. It also showed that in the development of neoplasia, stromal fascin expression decreases but epithelial fascin expression up-regulates.

Keywords

Endometrium; Endometrioid carcinomas; Fascin; Angiogenesis; Prognosis

Cite and Share

S. Kabukcuoglu,V. Oner,S.S. Ozalp,E. Dundar,O.T. Yalcin,E. Colak. Prognostic significance of f ascin expression in endometrioid carcinoma. European Journal of Gynaecological Oncology. 2006. 27(5);481-486.

References

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