Article Data

  • Views 220
  • Dowloads 126

Case Reports

Open Access

Malignant mixed Mtillerian tumor with heterologous component arising in the fallopian tube - a case report

  • G. Hudelist1,*,
  • K. Unterrieder1
  • O. Kandolf1
  • G. Alpi2
  • S. Pucher2
  • G. Pollak2
  • K. Czerwenka3
  • J. Keckstein1

1Department of Obstetrics and Gynecology, LKH Villach, Austria

2Department of Pathology, LKH Villach, Austria

3Department of Clinical Pathology, Division of Gynecopathology, University of Vienna Medical Center, Austria

DOI: 10.12892/ejgo200605509 Vol.27,Issue 5,September 2006 pp.509-512

Published: 10 September 2006

*Corresponding Author(s): G. Hudelist E-mail:

Abstract

Primary malignant mixed Müllerian tumors (MMMTs) of the fallopian tube are rarities in gynecologic oncology with only 26 cases of MMMTs with a heterologous component reported thus far. We report a case of FIGO Stage II primary MMMT of the fallopian tube with a heterologous tumor portion in an 80-year-old woman presenting with abdominal discomfort at the time of primary diagnosis. After performance of total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy follow-up examination three months postoperatively did not show signs of disease recurrence. The patient finally presented six months after the initial diagnosis with extensive intraabdominal metastasis and died several days thereafter. The present report supports the aggressive nature of these neoplasms. The efficacy of chemotherapy and radiation remains to be defined in future studies.

Keywords

Malignant mixed Muellerian tumor; Fallopian tube; Histogenesis

Cite and Share

G. Hudelist,K. Unterrieder,O. Kandolf,G. Alpi,S. Pucher,G. Pollak,K. Czerwenka,J. Keckstein. Malignant mixed Mtillerian tumor with heterologous component arising in the fallopian tube - a case report. European Journal of Gynaecological Oncology. 2006. 27(5);509-512.

References

[1] Humble S., Carter E.: "Pathologic quiz case: a right adnexal mass in a postmenopausal patient. Malignant mixed mullerian tumor with heterologous elements arising in the fallopian tube". Arch Pathol. Lab. Med., 2004, 128, 161.

[2] Lim BJ., Kim J.W., Yang W.I., Cho N.H.: "Malignant mixed mullerian tumor of fallopian tube with multiple distinct heterologous components". Int. J. Gynecol. Cancer, 2004, 14, 690.

[3] Imachi M., Tsukamoto N., Shigematsu T., Watanabe T., Uehira K., Amada S. et al.: "Malignant mixed Mullerian tumor of the fall opian tube: report of two cases and review of literature". Gynecol Oneal., 1992, 47, 114.

[4] Maitra R.N., Lee J., McConnell D.T., Kenwright D.N., Dady P "Malignant mixed mullerian tumour of the fallopian tube occurring in a patient with Peutz-Jegher's syndrome". Aust. N.Z.J. Obstet. Gynaecol., 2004, 44, 77.

[5] Kuroda N., Moriki T., Oguri H., Maeda N., Toi M., Miyazaki E., et al.: "Malignant mullerian mixed tumor (carcinosarcoma) of the fallopian tube: an immunohistochemical study of neoplastic cells". Apmis, 2005, 113, 643.

[6] Horn L.C., Werschnik C., Bilek K., Emmert C.: "Diagnosis and clinical management in malignant Mullerian tumors of the fallopian tube. A report of four cases and review of recent literature" Arch. Gynecol. Ohstet., 1996, 258, 47.

[7] Costa M.J., Guinee D. Jr.: "CD34 immunohistochemistry in female genital tract carcinosarcoma (malignant mixed mullerian tumors) supports a dominant role of the carcinomatous component". Appl. Immunohistochem. Mol. Morphol., 2000, 8, 293.

[8] Shen D.H., Khoo U.S., Xue W.C., Ngan H.Y., Wang J.L., Liu V.W. et al.: "Primary peritoneal malignant mixed Mullerian tumors. A clinicopathologic, immunohistochemical, and genetic study" Cancer, 2001, 91, 1052.

[9] Gagner J.P., Mittal K.: "Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma". Gynecol. Oncol., 2005, 97, 219.

[10] Fujii H., Yoshida M., Gong Z.X., Matsumoto T., Hamano Y., Fuku naga M. et al.: "Frequent genetic heterogeneity in the clonal evolution of gynecological carcinosarcoma and its influence on phenotypic diversity". Cancer Res., 2000, 60, 114.

[11] Emoto M., Iwasaki H., Kikuchi M., Shirakawa K.: "Characteristics of cloned cells of mixed mullerian tumor of the human uterus. Carcinoma cells showing myogenic differentiation in vitro". Cancer, 1993, 71, 3065.

[12] Gorai I., Yanagibashi T., Taki A., Udagawa K., Miyagi E., Nakazawa T. et al.: "Uterine carcinosarcoma is derived from a single stem cell: an in vitro study". Int. J. Cancer, 1997, 72, 821.

[13] Zelmanowicz A., Hildesheim A., Sherman M.E., Sturgeon S.R., Kurman R.J., Barrett R.J. et al.: "Evidence for a common etiology for endometrial carcinomas and malignant mixed mullerian tumors". Gynecol. Oneal., 1998, 69, 253.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top