Fulminant course of metastatic liposarcoma after delivery -case report

Abdominal liposarcoma is a rare tumor of uncertain prognosis. Radical surgery is possible in about two-thirds of the patients, and the prognosis of patients with inoperable tumors is dismal. Only a few cases of liposarcoma complicating pregnancy have been documented. We report a case of a patient who was diagnosed with metastatic abdominal liposarcoma during the third trimester of the pregnancy. After induced vaginal delivery, palliative surgery was performed and one cycle of systemic combination chemotherapy was administered. Despite the multimodality treatment the patient died of progressive disease within one month after diagnosis. Autopsy revealed high-grade pleomorphic liposarcoma arising from the retroperitoneum with liver and lung metastases.

Liposarcoma; Pregnancy; Retroperitoneum

[1] Jaques D.P., Coit D.G., Hajdu S.I., Brennan M.F.: "Management of primary and recurrent soft-tissue sarcoma of the retroperitoneum" Ann. Surg., 1990, 212, 51.

[2] Yamamoto T., Marui T., Akisue T., Hitora T., Kawamoto T., Nagira K. et al.: "Management of liposarcoma occurring in pregnant women". Anticancer Res., 2003, 23, 799.

[3] Frank P., Batzenschlager A., Schaeffer F., Irrmann M.: "Problemes thréapeutiques poses par Jes liposarcomes intra-abdominaux" Chirurgie 1989,JJ5, 446.

[4] Tebes S., Cardosi R., Hoffman M.: "Liposarcoma complicatmg pregnancy". Gynecol. Oncol., 2001, 83,610.

[5] De Jaco P., Giorgio M., Zantedeschi B., Mazzoleni G., Marabini A "A case of retroperitoneal liposarcoma in pregnancy". Acta Obste Gynecol. Scand., 1993, 72, 122.

[6] Khelifati Y., Abd-Alsamad I., Haddad B., Touboul C., Scherer A., Paniel B.J.: "Liposarcome myxoide pelvien. A propos d'un cas". J Gynecol. Obstet. Biol. Reprod., 1995, 24, 264. [7] Foruhan B.: "Retroperitoneal sarcomas obstructing delivery. Two case reports". 81: J. Obstet. Gynaecol., 1979, 86, 9.