The role of HPV DNA in the evaluation and follow-up of asymptomatic male sexual partners of females with CIN3

Purpose: To determine whether and how asymptomatic sexual partners of females with high-grade cervical intraepithelial neoplasia (CIN3) lesions should be examined. Methods: Sexual partners of females with CIN3 were evaluated for HPV-related lesions by scraping samples for high-risk HPV DNA and androscopy (colposcopic inspection of the penis, scrotum and peri-anal area). Abnormal androscopically detected lesions were sampled for cytology by Pap smears. Results: 74 partners of 87 females were studied and underwent androscopy, and 17 (22.9%) had abnormal findings: 11/74 had clinical genital condyloma acuminata and 6/74 had aceto-white lesions on the penile shaft or scrotum. Cytology of the 17 abnormal androscopies showed that six smears were normal and 11 had atypia and koilocytosis. Positive high-risk HPV DNA indicated that 13/74 (17.5 %) were infected with HPV. Two partners (2/74, 2.8%) had concomitant HPV DNA 16. Conclusions: Male sexual partners of females with CIN3 should undergo androscopy and cytology of colposcopically detected abnormal areas.

Male sexual partners of females with CIN3; Androscopy, HPV DNA testing in males

[1] Mosciciki A.B.: "Impact of HPV infection in adolescent populations". J. Adolesc. Health, 2005, 37 (suppl.), S3.

[2] Baldwin S.B., Wallace D.R., Papenfuss M.T., Abrahamsen M., Vaught L.C., Giuliano A.R.: "Condom use and other factors affecting penile human papillomavirus detection in men attending a sexually transmitted disease clinic". Sex Trans. Dis., 2004, 31, 601.

[3] Hippelainen M., Syrjanen S., Hippelainen M., Koskela H., Pulkkenen J., Saarikoski S. et al.: "Prevalence and risk factors of genital human papillomavirus (HPV ) infections in healthy males: a study on Finnish conscripts". Sex Transm. Dis., 1993, 20, 321.

[4] Takahashi S., Takahashi K., Miyamoto S., Ichihara K., Maeda T., Kunishima Y. et al.: "Incidence of sexually transmitted infections in asymptomatic healthy young Japanese men". J. Infect. Chemother., 2005, 11, 270.

[5] Hama N., Ohtsuka T., Ymazaki S.: "Squamous cell carcinoma of the penis in a man with human papilloma virus 31 infection". J. Dermatol., 2005, 32, 581.

[6] Aguilar L.V., Lazcano-Ponce E., Vaccarella S., Cruz A., Hernandez P., Smith J.S. et al.: "Human papillomavirus in men: comparison of different genital sites". Sex Transm. Infect., 2006, 82, 31.

[7] Nicolau S.M., Camargo C.G., Stavale J.N., Castelo A., Dores G.B., Lorincz A. et al.: "Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection". Urology, 2005, 65, 251.

[8] van der Snoek E.M., Niesters H.G., Mulder P.O., van Doornum G.J., Osterhaus A.O., van der Meijden W.l.: "Human papillomavirus infection in men who have sex with men participating in a Dutch gay-cohort study". Sex Transm. Dis., 2003, 30, 639.

[9] Castellsague X., Ghaffari A., Daniel R.W., Bosch F.X., Munoz N., Shah K.V.: "Prevalence of penile human papillomavirus DNA in husbands of women with and without cervical neoplasia: a study in Spain and Columbia". J. Infect. Dis., 1997, 176, 353.

[10) Costa S., Syrjanen S., Vendra C., Chang F., Guida G., Tervahauta A. et al.: "Detection of human papillomavirus infections in the male sexual partners of women attending an STD clinic in Bologna". Int. J STD AIDS, 1992, 3, 338.

[11] Schiffman M., Castle P.E.: "Human papillomavirus: epidemiology and public health". Arch. Pathol. Lab. Med., 2003, 127, 930.