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Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report

  • A. Cetin1
  • Z. Bahat2,*,
  • P. Cikesiz1
  • N. Demirbag3
  • E. Yavuz4

1Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Turkey

2Department of Oncology, Haseki Education and Research Hospital, Turkey

3Department of Pathology, Haseki Education and Research, Turkey

4Department of Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey

DOI: 10.12892/ejgo200703241 Vol.28,Issue 3,May 2007 pp.241-244

Published: 10 May 2007

*Corresponding Author(s): Z. Bahat E-mail:

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Abstract

Background: Alpha-fetoprotein (AFP) is a useful tumor marker for germ cell tumors of the ovary and is valuable for both diagnosis and follow-up. However, it is very rare for an epithelial ovarian carcinoma to secrete AFP.

Case: We report a case of a 63-year-old woman with a ovarian clear cell carcinoma with serous component of less than 10%. Both histological components were producing AFP as demonstrated by immunohistochemistry. After surgery and chemotherapy, AFP decreased to normal range. The patient also had elevated CA-125 levels but the tumor was negative for CA-125 which suggested the increased CA-125 might have been due to the associated ascites.

Conclusion: Ovarian clear cell type carcinomas rarely secrete only AFP and it might be the single marker that could be used in follow-up.

Keywords

Clear cell carcinoma; Serous adenocarcinoma; Epithelial ovarian carcinoma; Tumor marker; AFP; CA-125

Cite and Share

A. Cetin,Z. Bahat,P. Cikesiz,N. Demirbag,E. Yavuz. Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report. European Journal of Gynaecological Oncology. 2007. 28(3);241-244.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200703241

References

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[2] Matsuta M., Ishikura H., Murakami K., Kagabu T., Nishiya I "Hepatoid cancer of the ovary: a case report". Int. J. Gynecol Pathol., 1991, 10, 302.

[3] Konishi I., Fujii S., Kataoka N., Noda Y., Okamura H., Yarnabe H., et al.: "Ovarian mucinous cystadenocarcinorna producing alphafetoprotein". Int. J. Gynecol. Pathol.. I 988, 7I, 82.

[4] Maida Y., Kyo S., Ta灿kura M., Kanaya T., Inoue M.: "Ovanan endometrioid adenocarcinorna with ectopic production of alphafetoprotein". Gynecol. Oncol., 1998, 71, 133.

[5] Nogales FF., Bergeron C., Carvia R.E., Alvaro T., Fulwood H.R "Ovarian endometrioid tumors with yolk sac tumor component, an unusual form of ovarian neoplasm: Analysis of six cases". Am J. Surg. Pathol., 1996, 20, 1056.

[6] Ramalingam P., Malpica A., Silva E.G., Gershenson D.M., Liu J.L., Deavers M.T.: "The use of cytokeratin 7 and EMA in differentiating ovarian yolk sac tumors from endometrioid and clear cell carcinomas". Am. J. Surg. Pathol., 2004, 28, 1499.

[7] Clear Cell Adenocarcinoma World Health Organization Classificatioo of Tumours Pathology and Genetics/Tumours of Breast and Female Genital Organs. In: H.A. Tavassol and P. Device (eds.). International Agency for Research on Cancer (IARC) Lyon, France, 2003, 137.

[8] Topalak 0., Sayg山U., Soyturk M., Karaca N., BaturY., Uslu T. et al.: "Serum, pleural effusion, and ascites CA-125 levels in ov,trian cancer and nonovarian benign and malignant diseases: a comparative study". Gynecol. Oneal., 2002, 85, 108.

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