Genetic imbalance and human papillomavirus states in vulvar squamous cell carcinomas

Purpose of investigation: Vulvar squamous cell carcinoma (VSCC) is a disease of significant clinical importance, which arises in the presence or absence of human papillomavirus (HPV). Methods: We used comparative genomic hybridization (CGH) to document non-random chromosomal gains and losses with HPV positive and negative VSCCs. Results: Gains of 3q and 12q were significantly more common in HPV-positive cancers compared to HPV-negative cancers where chromosome 8q was more commonly gained in HPV-negative compared to HPV-positive cancer chromosomes and, 4p and 3p were lost in both categories of VSCCs. Conclusions: The data indicate that one or more oncogenes important in the development and progression of HPV-induced carcinomas are located on 3q and 12q.

Vulvar squamous cell carcinomas (VSCC); Comparative genomic hybridization (CGH); Human papillomavirus (HPV)

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