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Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report

  • E. E rdemoglu1,*,
  • S. Ozen2

1Department of Obstetrics and Gynecology, Turkey

2Department of Pathology, Faculty of Medicine, Yiiziincii Yll University, Van, Turkey

DOI: 10.12892/ejgo200706516 Vol.28,Issue 6,November 2007 pp.516-518

Published: 10 November 2007

*Corresponding Author(s): E. E rdemoglu E-mail:

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Abstract

Background: Gonodoblastomas with ovarian germ cell tumors (OGCTs) other than dysgerminoma are very unusual. This is the first case report of a pure endodermal sinus tumor of the ovary with gonodoblastoma in a 46 XX, female. Case: A 19-year-old female was admitted to our hospital with an abdominal mass and pain. She had elevated levels of CA-125 and AFP. Fertility sparing surgery was undertaken and revealed a Stage IA endodermal sinus tumor and gonodoblastoma in the same ovary. The patient refused chemotherapy and was followed-up for six months without disease. Conclusion: Gonodoblastomas may occur in conjunction with OGCTs. Tumor markers and immunohistochemical examination may help in the diagnosis of these OGCTs with gonodoblastoma.

Keywords

Gonodoblastoma; Endodermal sinus tumor; Yolk sac tumor; Immunohistochemistry; Tumor markers

Cite and Share

E. E rdemoglu,S. Ozen. Ovarian gonodoblastoma with yolk sac tumor in a young 46, XX female: case report. European Journal of Gynaecological Oncology. 2007. 28(6);516-518.

URL:

https://www.ejgo.net/articles/10.12892/ejgo200706516

References

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[2] Berek J.S., Hacker N.F.: "Nonepithelial ovarian and fallopian tube cancers". In E. Berek J.S., Hacker N.F. (eds.), Practical Gynecologic Oncology, 4th edition. Philadelphia, Lippincott Williams and Wilkins, 2005, 511.

[3] Talerman A., Verp M.S., Senekjian E., Gilewski T., Vogelzang N.: "True hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, 46,XX/46,XY karyotype, and a successful pregnancy". Cancer, 1990, 66, 2668.

[4] Pauls K., Franke F.E., Buttner R., Zhou H.: "Gonadoblastoma: evidence for a stepwise progression to dysgerminoma in a dysgenetic ovary". Virchows Arch., 2005, 447, 603.

[5] Obata N.H., Nakashima N., Kawai M., Kikkawa F., Mamba S., Tomoda Y.: "Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype". Gynecol. Oneal., 1995, 58, 124.

[6] Zhao S., Noriko Kato, Endoh Y., Jin Z., Ajioka Y., Motoyama T.: "Ovarian gonadoblastoma with mixed germ cell tumor in a woman with 46,XX karyotype and successful pregnancies". Pathol. Int., 2000, 50, 332.

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