Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Relationship between risk factors and tumor stage in breast cancer patients in a university hospital - Brazil
1Department of Biological Sciences, Brazil
2Research Institute of Oncology (IPON)/Discipline of Gynecology and Obstetrics, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil
*Corresponding Author(s): B.M. Tavares-Murta E-mail: bmurtafarmaco@dcb.uftm.edu.br
Purpose: To verify the relationship between clinical variables and tumor stage in breast cancer. Methods: This retrospective study (1998 to 2001) analyzed data of 176 women with breast cancer attending a university hospital. Patients were divided into groups according to the clinicopathological variables studied. Results: The disease had a similar frequency at age under 50 years (44.3%) or above (55.7%) 50 years. Stage II was more frequent. Most patients were white (69.9%), non-smokers (69.3%) and were not using oral contraceptives (71%). Stages 0-II were mainly detected in the white (74.8%) vs non-white (60.4%) group. Monthly breast self-exams were performed by 62.5% of women, in which earlier stages (0, I) were more frequently detected than in those who did not perform self-exams (27.3% vs 12.1%, p = 0.01). Conclusion: Breast cancer occurred mainly in white women in Stage II, and with similar frequency at age under or over 50 years. Breast self-exam was associated with early detection of the disease.
Breast cancer; Tumor stage; Risk factors; Breast self-exam
M.A.O. Mendonça,B.M. Tavares-Murta,E.S. Bachin,L.B. Davi,E.F.C Murta. Relationship between risk factors and tumor stage in breast cancer patients in a university hospital - Brazil. European Journal of Gynaecological Oncology. 2008. 29(1);80-82.
[1] Alberg A.J., Singh S., May J.W., Helzlsouer K.J.: “Epidemiology, prevention, and early detection of breast cancer”. Curr. Opin. Oncol., 2000, 12, 515.
[2] Johnson-Thompson M.C., Guthrie J.: “Ongoing research to identify environmental risk factors in breast carcinoma”. Cancer, 2000, 88, 1224.
[3] Falkenberry S.S., Legare R.D.: “Risk factors for breast cancer”. Obstet. Gynecol. Clin. North. Am., 2002, 29, 159.
[4] Kelsey J.L., Horn-Ross P.L.: “Breast cancer: magnitude of the problem and descriptive epidemiology”. Epidemiol. Rev., 1993, 15, 7.
[5] Noyes R.D., Spanos W.J. Jr, Montague E.D.: “Breast cancer in women aged 30 and under”. Cancer, 1982, 49, 1302.
[6] La Rochefordiere A., Asselain B., Campana F., Scholl S.M., Fenton J., Vilcoq J.R. et al.: “Age as prognostic factor in premenopausal breast carcinoma”. Lancet, 1993, 34, 1039.
[7] Buiatti E., Barchielli A., Bartolacci S., Bucchi L., De L.V., Frederico M. et al.: “Stage-specific incidence of breast cancer before the beginning of organized screening programs in Italy”. Cancer Causes Control., 2002, 13, 65.
[8] Pinotti J.A., Tojal M.L., Nisida A.C., Pinotti M.: “Integrated approach to women’s health”. Int. J. Gynecol. Obstet., 2000, 70, 191.
[9] Weiss N.S.: “Breast cancer mortality in relation to clinical breast examination and breast self-examination”. Breast J., 2003, 2, S86.
[10] Kosters J.P., Gotzsche P.C.: “Regular self-examination or clinical examination for early detection of breast cancer”. Cochrane Database Syst Rev., 2003, 2, CD003373.
[11] Beahrs, O.H.: “Staging of cancer of the breast as a guide to therapy”. Cancer, 1984, 53, 592.
[12] Jensen O., Esteve J., Moller H., Renard H.: “Cancer in the European Community and its member states”. Eur. J. Cancer, 1990, 26, 1167.
[13] Lannin D.R., Mathews H.F., Mitchell J., Swanson M.S., Swanson F.H., Edwards M.S.: “Influence of socioeconomic and cultural factors on racial differences in late-stage presentation of breast cancer”. JAMA, 1998, 279, 1801.
[14] Jatoi I., Anderson W.F., Rao S.R., Devesa S.S.: “Breast cancer trends among black and white women in the United States”. J. Clin. Oncol., 2005, 23, 7836.
[15] Wingo P.A., Calle E.E., McTiernan A.: “How does breast cancer mortality compare with that of other cancers and selected cardiovascular diseases at different ages in U.S. women?” J. Womens Health Gend. Based. Med., 2000, 9, 999.
[16] El Saghir N.S., Shamseddine A.I., Geara F., Bikhazi K., Rahal B., Salem Z.M. et al.: “Age distribution of breast cancer in Lebanon: increased percentages and age adjusted incidence rates of younger-aged groups at presentation”. J. Med. Liban., 2002, 50, 3.
[17] Ikpat O.F., Ndoma-Egba R., Collan Y.: “Influence of age and prognosis of breast cancer in Nigeria”. East. Afr. Med. J., 2002, 79, 651.
[18] Jayasinghe U.W., Taylor R., Boyages J.: “Is age at diagnosis an independent prognostic factor for survival following breast cancer?” ANZ. J. Surg., 2005, 75, 762.
[19] Collaborative Group on Hormonal Factors in Breast Cancer. Breast cancer and hormonal contraceptives: collaborative reanalysis of individual data on 53,297 women with breast cancer and 100,239 women without breast cancer from 54 epidemiological studies. Lancet, 1996, 347, 1713.
[20] Kumle M., Weiderpass E., Braaten T., Person I., Adami H.D., Lund E.: “Use of oral contraceptives and breast cancer risk: The Norwegian-Swedish Women's Lifestyle and Health Cohort Study”. Cancer Epidemiol. Biomarkers. Prev., 2002, 11, 1375.
[21] Brekelmans C.T.: “Risk factors and risk reduction of breast and ovarian cancer”. Curr. Opin. Obstet. Gynecol., 2003, 15, 63.
[22] Silvera S.A.N, Miller A.B., Rohan T.E.: “Oral contraceptive use and risk of breast cancer among women with a family history of breast cancer: a prospective cohort study”. Cancer Causes Control, 2005, 16, 1069.
[23] Milne R.L., Knight J.A., John E.M., Dite G.S., Balbuena R., Ziogas A. et al.: “Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations”. Cancer Epidemiol. Biomark. Prev., 2005, 14, 350.
[24] Hamajimaet N., Hirose K., Tajima K., Rohan T., Calle E.E., Heath C.W. Jr, et al.: “Alcohol, tobacco and breast cancer – collaborative reanalysis of individual data from 53 epidemiological studies including 58,515 women with breast cancer and 95,067 without the disease”. Br. J. Cancer, 2002, 18, 1234.
[25] Fentiman I.S., Allen D.S., Hamed H.: “Smoking and prognosis in women with breast cancer”. Int. J. Clin. Pract., 2005, 59, 1051.
[26] Gram I.T., Braaten T., Terry P.D., Sasco A.J., Adami H.O., Lund E. et al.: “Breast cancer risk among women who start smoking as teenagers”. Cancer Epidemiol. Biomark. Prev., 2005, 14, 61.
[27] Parkin D.M., Bray F.I., Devesa S.S.: “Cancer burden in the year 2000. The global picture”. Eur. J. Cancer, 2001, 37, 64.
[28] Miller A.B., To T., Baines C.J., Wall C.: “Canadian National Breast Screening Study-2: 13-year results of a randomized trial in women aged 50-59 years”. J. Natl. Cancer Inst., 2000, 92, 1490.
[29] Thomas D.B., Gao D.L., Ray R.M., Wang W.W., Allison C.J., Chen F.L. et al.: “Randomized trial of breast self-examination in Shanghai: final results”. J. Natl. Cancer Inst., 2002, 94, 1445.
Top