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Recurrence of granulosa cell tumor 25 years after initial diagnosis. Report of a case and review of the literature
12nd Department of Obstetrics and Gynecology, Greece
2Department of Pathology, University of Athens, School of Medicine, Aretaieion Hospital, Athens, Greece
*Corresponding Author(s): K. Papakonstantinou E-mail: kpapakon@yahoo.gr
Granulosa cell tumors (GCTs) are rare functional sex cord-stromal ovarian tumors constituting approximately 2-3% of all ovarian malignancies. They are characterized by low malignant potential, local spread, late recurrence and high survival rates. We report a case of recurrent ovarian GCT in a 60-year-old woman 25 years after the initial diagnosis. The patient underwent surgical resection of the pelvic masses and refused to receive any adjuvant treatment, considering the late recurrence and high survival rates of this tumor. This case illustrates an example of a very late recurrence and emphasizes the importance of the extended follow-up required for these patients.
Adult granulosa cell tumor; Recurrence
D. Hasiakos,K. Papakonstantinou,E. Karvouni,S. Fotiou. Recurrence of granulosa cell tumor 25 years after initial diagnosis. Report of a case and review of the literature. European Journal of Gynaecological Oncology. 2008. 29(1);86-88.
[1] Young R.H., Scully R.E.: “Granulosa-stromal cell tumors”. In: Kurman R.J. (ed.), Blaustein’s Pathology of the Female Genital Tract, 5th edn. New York, Springer, 2002, 906.
[2] Malmstrom H., Hogberg T., Risberg B., Simonsen E.: “Granulosa cell tumors of the ovary: Prognostic factors and outcome”. Gynecol. Oncol., 1994, 52, 50.
[3] Hines J.F., Khalifa M.A., Moore J.L., Fine K.P., Lage J.M., Barnes W.A.: “Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: A case report and review of the literature”. Gynecol. Oncology, 1996, 60, 484.
[4] Singh-Ranger G., Sharp A., Crinnion J.N.: “Recurrence of granulose cell tumour after thirty years with small bowel obstruction”. Int. Sem. Surg. Oncol., 2004, 1, 4.
[5] Cronje H.S., Niemand I., Bam R.H., Woodruff J.D.: “Review of the granulosa-theca cell tumors of the Emil Novak ovarian tumor registry”. Am. J. Obstet. Gynecol., 1999, 180, 323.
[6] Bjorkholm E., Silfversward C.: “Prognosis factors in granulosa cell tumors”. Gynecol. Oncol., 1981, 11, 261.
[7] Nakashima N., Young R.H., Scully R.E.: “Androgenic granulosa cell tumors of the ovary. A clinicopathologic analysis of 17 cases and review of the literature”. Arch. Pathol. Lab. Med., 1984, 108, 786.
[8] Wolf J.K., Mullen J., Eifel P.J., Burke T.W., Levenback C., Gershenson D.M.: “Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary”. Gynecol. Oncol., 1999, 73, 35.
[9] Uygun K., Aydiner A., Saip P., Kocak Z., Basaran M., Dincer M., Topuz E.: “Clinical parameters and treatment results in recurrent granulosa cell tumor of the ovary”. Gynecol. Oncol., 2003, 88, 400.
[10] Hardy R., Bell J., Nicely C., Reid G.: “Hormonal treatment of a recurrent granulosa cell tumr of the ovary: case report and review of the literature”. Gynecol. Oncol., 2005, 96, 865.
[11] Jobling T., Mamers P., Healy D.L., MacLachlan V., Burger H.G., Quinn M. et al.: “A prospective study of inhibin in granulosa cell tumors of the ovary”. Gynecol. Oncol., 1994, 55, 285.
[12] Hasiakos D., Papakonstantinou K., Goula K., Karvouni E., Fotiou S.: “Juvenile granulosa cell tumor associated with pregnancy. Report of a case and review of the literature”. Gynecol. Oncol., 2006, 100, 426.
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