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Paget’s disease of the vulva. A ten-year experience
12nd Department of Obstetrics and Gynecology, University of Athens, Aretaieion Hospital, Athens, Greece
*Corresponding Author(s): C. Iavazzo E-mail: christosiavazzo@hotmail.com
Background: Paget's disease of the vulva is a rare neoplasmatic lesion which mainly affects postmenopausal women. Method: Results: We conducted a retrospective study during the period January 1996 till December 2005 in which I I cases of Paget's disease were detected. The clinical manifestations, management, specific pathological features, treatment and prognosis of each patient are presented. Conclusion: Surgical treatment is the current standard and long-term follow-up is required.
Paget’s disease of the vulva; Diagnosis; Management; Prognosis
K. Bakalianou,N. Salakos,C. Iavazzo,G. Paltoglou,K. Papadias,O. Gregoriou,A. Kondi-Pafiti. Paget’s disease of the vulva. A ten-year experience. European Journal of Gynaecological Oncology. 2008. 29(4);368-370.
[1] Dubreilh W.: “Paget’s disease of the vulva”. Br. J. Dermatol., 1901, 13, 407.
[2] Curtin J.P., Rubin S.C., Jones W.B., Hoskins W.J., Lewis J.L.: “Paget’s disease of the vulva”. Gynecol. Oncol., 1990, 39, 374.
[3] Billings S.D., Roth L.M.: “Pseudoinvasive, nodular extramammary Paget’s disease of the vulva”. Arch. Pathol. Lab. Med., 1998, 122, 471.
[4] Parker L.P. et al.: “Paget’s disease of the vulva: pathology, pattern of involvement and prognosis”. Gynecol. Oncol., 2000, 77, 183.
[5] Hoffman M.S., Gavanagh D.: “Malignancies of the vulva”. In: Rock J.A., Thompson J.D., (eds.): “Telinde’s Operative Gynecology”. 9th edition, Philadelphia, Lippincott-Raven, 2003, 1335.
[6] Gull S.E., Al-Rufaie H.K.: “Paget’s disease of the vulva with underlying in situ and invasive classical lobular breast carcinoma”. J. Obstet. Gynaecol., 1999, 19, 320.
[7] Ohira S., Itoh K., Osada K., Oka K., Suzuki A., Osada R. et al.: “Vulvar Paget’s disease with underlying adenocarcinoma simulating breast carcinoma: case report and review of the literature”. Int. J. Gynecol. Cancer, 2004, 14, 1012.
[8] Pierie J.P., Choudry U., Muzikansky A., Finkelstein D.M., Ott M.J.: “Prognosis and management of extramammary Paget’s disease and the association with secondary malignancies”. J. Am. Coll. Surg., 2003, 196, 45.
[9] Awtrey C.S., Marshall D.S., Soslow R.A., Chi D.S.: “Clinically inapparent invasive vulvar carcinoma in an area of persistent Paget’s disease: a case report”. Gynecol. Oncol., 2003, 88, 440.
[10] Habif T.P.: “Clinical Dermatology: a Color Guide to Diagnosis and Therapy”, 3rd edition, St. Louis, Mosby 1996.
[11] Petkovic S., Jeremic K., Vidakovic S., Jeremic J., Lazovic G.: “Paget’s disease of the vulva – a review of our experience”. Eur. J. Gynaecol. Oncol., 2006, 27, 611.
[12] Niikura H., Yoshida H., Ito K., Takano T., Watanabe H., Aiba S., Yaegashi N.: “Paget’s disease of the vulva: clinicopathologic study of type 1 cases treated at a single institution”. Int. J. Gynecol. Cancer, 2006, 16, 1212.
[13] MacLean A.B., Makwana M., Ellis P.E., Cunnington F.: “The management of Paget’s disease of the vulva”. J. Obstet. Gynaecol., 2004, 24, 124.
[14] Curtin J.P., Rubin S.C., Jones W.B., Hoskins W.J., Lewis J.L.: “Paget’s disease of the vulva”. Gynecol. Oncol., 1990, 39, 374.
[15] Tebes S., Gardosi R., Hoffman M.: “Paget’s disease of the vulva”. Am. J. Obstet. Gynecol., 2002, 187, 281.
[16] Fanning J., Lambert L., Halle T., Morris P., Schuerch C.: “Paget’s disease of the vulva: prevalence of associated vulvar adenocarcinoma, invasive Paget’s disease, and recurrence after surgical excision”. Am. J. Obstet. Gynecol., 1999, 180, 24.
[17] Piura B., Rabinovich A., Dgani R.: “Extramammary Paget’s disease of the vulva: report of five cases and review of the literature”. Eur. J. Gynecol. Oncol., 1999, 20, 98.
[18] Tinari A., Pace S., Fambrini M., Eleuteri Serpieri D., Frega A.: “Vulvar Paget’s disease: review of the literature, considerations about histogenetic hypothesis and surgical approaches”. Eur. J. Gynaecol. Oncol., 2002, 23, 551.
[19] Helwig E.B., Graham J.H.: “Anogenital extramammary Paget’s disease”. Cancer, 1963, 16, 387.
[20] Sideri M. et al.: “Squamous vulvar intraepithelial neoplasia. 2004 modified terminology, ISSVD Vulvar Oncology Subcommittee”. J. Reprod. Med., 2005, 50, 807.
[21] Gu M., Ghafari S., Lin F.: “Pap smears of patients with extramammary Paget’s disease of the vulva”. Diagn. Cytopathol., 2004, 32, 353.
[22] Kodama S., Kaneko T., Saito M., Yoshiya N., Honma S., Tanaka K.: “A clinicopathologic study of 30 patients with Paget’s disease of the vulva”. Gynecol. Oncol., 1995, 56, 63.
[23] Bergen S., DiSaia P.J., Liao S.Y., Berman M.L.: “Conservative management of extramammary Paget’s disease of the vulva”. Gynecol. Oncol., 1989, 33, 151.
[24] Stacy D., Burrell M.O., Franklin E.W.: “Extramammary Paget’s disease of the vulva and anus: use of intraoperative frozen-section margins”. Am. J. Obstet. Gynecol., 1986, 155, 519.
[25] Black D., Tornos C., Soslow R.A., Awtrey C.S., Barakat R.R., Chi D.S.: “The outcomes of patients with positive margins after excision for intraepithelial Paget’s disease of the vulva”. Gynecol. Oncol., 2007, 104, 547.
[26] Chin T., Murakami M., Hyakusoku H.: “Extramammary Paget’s disease of the vulva subclinically extending to the bladder neck: correct staging obtained with endoscopic urethral biopsy”. Int. J. Urol., 2004, 11, 689.
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