Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Primary malignant mixed müllerian tumour of the fallopian tube. Report of a case
1Department of Pathology, Tzaneion General Hospital of Piraeus, Greece
2Department of Anesthesiology, General Hospital of Larissa, Greece
*Corresponding Author(s): X. Grammatoglou E-mail: xanthippigrammatoglou@yahoo.gr
Malignant mixed müllerian tumour of the fallopian tube is an extremely rare lesion and to date only approximately 50 cases have been reported. The tumour is seldom distinguished preoperatively from other more common lesions or ovarian cancer. We report a case of a 60-year-old woman who presented to our hospital with pelvic pain. There was no clinical evidence of ascites or adenopathy. Ultrasound and abdominal and pelvic computed tomography showed a left adnexal mass. Total abdominal hysterectomy and bilateral salpingo-oophorectomy were carried out. Grossly the left side of the fallopian tube was dilated and the cut surface revealed a solid mass filling the entire lumen. Histological examinations showed a malignant mixed müllerian tumour. The tumor was an admixture of both carcinomatous and sarcomatous elements. The carcinomatous element was composed of well to moderately differentiated squamous cell carcinoma and the sarcomatous component was made up of anaplastic spindle shaped cells with hyperchromatic nuclei. An immunohistochemical study was performed. The patient was admitted to the anticancer hospital for further treatment. The prognosis of a primary malignancy of the fallopian tube is poor and depends more on staging than on histologic type and grade.
Fallopian tube; Mixed müllerian tumour; Immunohistochemistry.
E. Skafida,X. Grammatoglou,E. Katsamagkou,Ch. Glava,N. Firfiris,Th. Vasilakaki. Primary malignant mixed müllerian tumour of the fallopian tube. Report of a case. European Journal of Gynaecological Oncology. 2010. 31(1);126-128.
[1] Srivastava R., Sarma N.H.: “Primary squamous cell carcinoma of the fallopian tube. Report of a case and short review of primary malignancies of the fallopian tube”. Int. J. Med. Update, 2007, 2, 42.
[2] Lim B.J., Kim J.W., Yang W.I., Cho N.H.: “Malignant mixed mullerian tumor of fallopian tube. Distinct heterologous components”. Korean J. Pathol., 2003, 37, 429.
[3] Imachi M., Tsukamoto N., Shigematsu T., Watanabe T., Uehira K., Amada S. et al.: “Malignant mixed müllerian tumor of the fallopian tube: report of two cases and review of literature”. Gynecol. Oncol., 1992, 47, 114.
[4] Carlson J.A. Jr., Ackerman B.L., Wheeler J.E.: “Malignant mixed müllerian tumor of the fallopian tube”. Cancer, 1993, 71, 187.
[5] Hu Cy, Taymor M. L., Hertig A.T.: “Primary carcinoma of the fallopian tube”. Am. J. Obstet. Gynecol., 1950, 59, 58.
[6] Muntz H.G., Jones M.A., Goff B.A., Fuller A.F. Jr., Nikrui N., Rice L.W., Tarraza H.M.: “Malignant mixed müllerian tumors of the ovary: experience with surgical cytoreduction and combination chemotherapy”. Cancer, 1995, 76, 1209.
[7] Niloff J.M., Klug T.L., Schaetzl E., Zurawski V.R. Jr., Knapp R.C., Bast R.C. Jr.: “Elevation of serum CA125 in carcinomas of the fallopian tube, endometrium, and endocervix”. Am. J. Obstet. Gynecol., 1984, 148, 1057.
[8] Krishnan E., Coleman R.E.: “Malignant mixed mullerian tumours of gynaecological origin: chemosensitive but aggressive tumours”. Clin. Oncol. (R. Coll. Radiol.), 1998, 10, 246.
[9] Barnholtz-Sloan J.S., Morris R., Malone J.M. Jr., Munkarah A.R.: “Survival of women diagnosed with malignant, mixed mullerian tumors of the ovary (OMMMT)”. Gynecol. Oncol., 2004, 93, 506.
[10] Navarini R., Pineda R.L.: “Malignant mixed müllerian tumors of the ovary”. Curr. Opin. Obstet. Gynecol., 2006, 18, 20.
[11] Mok J.E., Kim Y.M., Jung M.H., Kim K.R., Kim D.Y., Kim J.H., et al.: “Malignant mixed müllerian tumors of the ovary: experience with cytoreductive surgery and platinum-based combination chemotherapy”. Int. J. Gynecol. Cancer, 2006, 16, 101.
[12] Sit A.S., Price F.V., Kelley J.L., Comerci J.T., Kunschner A.J., Kanbour-Shakir A., Edwards R.P.: “Chemotherapy for malignant mixed Müllerian tumors of the ovary”. Gynecol. Oncol., 2000, 79, 196.
[13] Costa M.J., Khan R., Judd R.: “Carcinoma (malignant mixed müllerian [mesodermal] tumor) of the uterus and ovary. Correlation of clinical, pathologic, and immunohistochemical features in 29 cases”. Arch. Pathol. Lab. Med., 1991, 115, 583.
[14] Ozguroglu M., Bilici A., Ilvan S., Turna H., Atalay B., Mandel N., Sahinler I.: “Determining predominating histologic component in malignant mixed müllerian tumors: is it worth it?”. Int. J. Gynecol. Cancer, 2008, 18, 809.
[15] Boucher D., Têtu B.: “Morphologic prognostic factors of malignant mixed müllerian tumors of the ovary: a clinicopathologic study of 15 cases”. Int. J. Gynecol. Pathol., 1994, 13, 22.
[16] Inthasorn P., Beale P., Dalrymple C., Carter J.: “Malignant mixed mullerian tumour of the ovary: prognostic factor and response of adjuvant platinum-based chemotherapy”. Aust. N.Z.J. Obstet. Gynaecol., 2003, 43, 61.
Top