Article Data

  • Views 250
  • Dowloads 113

Original Research

Open Access

Peritoneal mesotheliomas mimicking adnexal tumors. Clinicopathological characteristics of four cases and a short literature review

  • D. Dellaportas1
  • E. Kairi-Vassilatou1
  • P. Lykoudis1
  • P. Mavrigiannaki1
  • S. Mellou1
  • C.K. Kleanthis1
  • A. Kondi-Pafiti1,*,

1Pathology Laboratory, 2nd Department of Surgery, Aretaieion University Hospital, Athens, Greece

DOI: 10.12892/ejgo201201101 Vol.33,Issue 1,January 2012 pp.101-104

Published: 10 January 2012

*Corresponding Author(s): A. Kondi-Pafiti E-mail:


Three cases of peritoneal benign cystic mesotheliomas in women 32-34 years of age and one case of peritoneal malignant mesothelioma in a 47-year-old woman are reported. All cases presented with abdominal discomfort and/or pain and the physical and radiological diagnostic methods showed adnexal tumors. The cystic mesotheliomas developed in the cul-de-sac and the right pelvic side-wall, presented as multiple small cysts or large multilocular cystic mass. The malignant mesothelioma showed extensive infiltration of the omentum the intestinal loops and the surface of the uterus and adnexa, with bilateral hydrosalpinx and ascites. All cases presented histological and immunohistochemical characteristics consistent with tumors of mesothelial origin. No history of asbestos exposure was reported. The correct diagnostic and therapeutic approaches to these neoplasms are discussed.


Mesothelioma; Peritoneum; Immunohistochemistry

Cite and Share

D. Dellaportas,E. Kairi-Vassilatou,P. Lykoudis,P. Mavrigiannaki,S. Mellou,C.K. Kleanthis,A. Kondi-Pafiti. Peritoneal mesotheliomas mimicking adnexal tumors. Clinicopathological characteristics of four cases and a short literature review. European Journal of Gynaecological Oncology. 2012. 33(1);101-104.


[1] Boffetta P.: “Epidemiology of peritoneal mesothelioma: a review”. Ann. Oncol., 2007, 18, 985.

[2] Weiss S.W., Tavassoli F.A.: “Multicystic mesothelioma: an analysis of pathologic. findings and biologic behaviour in 37 cases”. Am. J. Surg. Pathol., 1988, 12, 737.

[3] Lee A.M., Raz D.J., He B., Jablons D.M.: “Update of the molecular biology of malignant mesothelioma”. Cancer, 2007, 109, 1454.

[4] Cutrone R., Lidnisk J., Dunn G., Rizzo P., Bocchetta M., Chumakov K. et al.: “Some oral poliovirus vaccine were contaminated with infectious SV40 after 1961”. Cancer Res., 2005, 65, 10273.

[5] Ross M.J., Welch W.R., Scully R.E.: “Multilocular peritoneal inclusion cysts (so called cystic mesotheliomas)”. Cancer, 1989, 64, 1336.

[6] Robinson B.W., Lake R.A.: “Advances in malignant mesothelioma”. N. Engl. J. Med., 2005, 353, 1591.

[7] Kazan-Allen L.: “Asbestos and mesothelioma: worldwide trends”. Lung Cancer, 2005, 49 (suppl. 1), S3.

[8] Peterson J.T. Jr., Greenberg S.D., Buffler P.A.: “Non-asbestos related malignant mesothelioma. A review”. Cancer, 1984, 54, 951.

[9] Lanphear B.P., Bucher C.R.: “Latent period for malignant mesothelioma of occupational origin”. J. Occup. Med., 1992, 34, 718.

[10] Sugarbaker P.H., Welch L.S., Mohamed F., Glehen O.: “A review of peritoneal mesothelioma at the Washington Cancer Institute”. Surg. Oncol. Clin. N. Am., 2003, 12, 605.

[11] Uzüm N., Ozçay N., Atao lu O.: “Benign multicystic peritoneal mesothelioma”. Turk. J. Gastroenterol., 2009, 20, 138.

[12] Hassan R., Remaley A.T., Sampson M.L., Zhang J., Cox D.D., Pingpank J.: “Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer”. Clin. Cancer Res., 2006, 12, 447.

[13] Safioleas M.C., Constantinos K., Michael S., Konstantinos G., Constantinos S., Alkiviadis K.: “Benign multicystic peritoneal mesothelioma: a case report and review of the literature”. World J. Gastroenterol., 2006, 12, 5739.

[14] Feldman A.L., Libutti S.K., Pingpank J.F., Bartlett D.L., Beresnev T.H., Mavroukakis S.M. et al.: “Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy”. J. Clin. Oncol., 2003, 21, 4560.

[15] Taub R.N., Hesdorffer M.E., Keohan M.L.: “Combined resection, intraperitoneal chemotherapy, and whole abdominal radiation for malignant peritoneal mesothelioma (MPM)”. J. Clin. Oncol., 2005, 23, 664s.

[16] Scagliotti G.V., Novello S.: “State of the art in mesothelioma”. Ann. Oncol., 2005 16 (suppl. 2), 240.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time