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Original Research

Open Access

Expression of beclin 1, an autophagy-related protein, in human cervical carcinoma and its clinical significance

  • H.Y. Cheng1
  • Y.N. ZHANG2,*,
  • Q.L. Wu3
  • X.M. Sun2
  • J.R. Sun2
  • X. Huang2

1Department of Obstetrics and Gynecology, Qingdao Central Hospital, Qingdao, Shandong, P. R. China

2Department of Gynecology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. China

3Department of Pathology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong, P. R. China

DOI: 10.12892/ejgo20120115 Vol.33,Issue 1,January 2012 pp.15-20

Published: 10 January 2012

*Corresponding Author(s): Y.N. ZHANG E-mail:


Purpose: To investigate the impact of beclin 1 on prognosis of cervical cancer, we determined the expression of beclin 1 in cervical cancer, cervical intraepithelial neoplasia (CIN) and normal cervical tissues. Methods: A total of 122 cases of cervical cancer, 35 cases with CIN and 31 cases with uterine fibroids were collected at the Cancer Center of Sun Yat University to determine the expression of beclin I. Results: Beclin l positive rate in normal cervical tissues, CIN tissues and cervical cancers was 83.9%, 74.3% and 53.3%, respectively, and it was significantly different between the three groups (p < 0.01). Beclin 1 expression was negatively correlated with cervical cancer differentiation, lymph node metastasis, recurrence and death (p < 0.05). The negative expression is the risk factor affecting overall survival (p < 0.05) and progression-free survival (PFS) (p < 0.05). Multivariate analysis showed that beclin 1 negative expression was an independent risk factor of PFS time. Conclusions: Beclin I may play a role in the occurrence and development of cervical cancer. Beclin 1 positive expression in patients indicates a better prognosis.


Cervical cancer; Autophagy; Beclin 1; Overall survival (OS); Progression-free survival (PFS)

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H.Y. Cheng,Y.N. ZHANG,Q.L. Wu,X.M. Sun,J.R. Sun,X. Huang. Expression of beclin 1, an autophagy-related protein, in human cervical carcinoma and its clinical significance. European Journal of Gynaecological Oncology. 2012. 33(1);15-20.


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