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Original Research

Open Access

Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer?

  • P. SALA1,*,
  • P. Marchiolè2
  • G. Cittadini3
  • M. Valenzano Menada1
  • M. Moioli1
  • S. Mammoliti4
  • S. Costantini1

1Operative Unit of Clinical Obstetrics and Gynecology, San Martino Hospital, University of Genoa, Genoa, Italy

2Department of Gynecology and Obstetrics, Villa Scassi Hospital-ASL3, Genoa, Italy

3Department of Radiology, San Martino Hospital, University of Genoa, Genoa, Italy

4Department of Medical Oncology, San Martino Hospital, Genoa, Italy

DOI: 10.12892/ejgo20120131 Vol.33,Issue 1,January 2012 pp.31-36

Published: 10 January 2012

*Corresponding Author(s): P. SALA E-mail: paolsala@gmail.com

Abstract

Objective: To evaluate the accuracy of magnetic resonance imaging (MRI) in staging cervical tumors after neoadjuvant chemotherapy (NACT). Methods: 26 women, affected by locally advanced cervical cancer and triaged for surgery after NACT, were submitted to three cycles of neoadjuvant chemotherapy. All patients were submitted to MRI before and after NACT. We evaluated the MRI sensitivity and specificity in staging cervical tumors after chemotherapy, relating MRI findings after NACT with the pathological findings as the gold standard. Results: In our series, MRI sensitivity was 58.8% and specificity was 66.7%. Conclusions: In our study MRI accuracy after NACT was lower than that of MRI used to stage patients with early cervical cancer scheduled for primary surgery, reported by the literature. MRI false negative cases are the major problem because of the delay in application of an effective therapy in non responders to NACT.

Keywords

Locally advanced cervical cancer (LACC); Neoadjuvant chemotherapy (NACT); Magnetic resonance imaging (MRI); Early response evaluation

Cite and Share

P. SALA,P. Marchiolè,G. Cittadini,M. Valenzano Menada,M. Moioli,S. Mammoliti,S. Costantini. Is magnetic resonance imaging useful in early evaluation of women on neoadjuvant chemotherapy for locally advanced cervical cancer?. European Journal of Gynaecological Oncology. 2012. 33(1);31-36.

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