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Original Research

Open Access

3D optical coherence tomography of cervical intraepithelial neoplasia - early experience and some pitfalls

  • J. Gallwas1,*,
  • R. Gaschler1
  • H. Stepp2
  • K. Friese1
  • C. Dannecker1

1Department of Obstetrics and Gynecology, Ludwig-Maximilians University, Munich, Germany

2Laser Forschungs Labor, Life Science Centre, Ludwig-Maximilians University, Munich, Germany

DOI: 10.12892/ejgo20120137 Vol.33,Issue 1,January 2012 pp.37-41

Published: 10 January 2012

*Corresponding Author(s): J. Gallwas E-mail:


Objectives: To compare two different systems for optical coherence tomography for the diagnosis of cervical dysplasia and to assess potential benefits of three-dimensional imaging. Materials and Methods: OCT images were taken from unsuspicious and suspicious areas of fresh conisation specimens using two different imaging systems, one with the capability to produce three-dimensional images. All OCT images were separately evaluated by two blinded investigators based on a 6-grade classification (normal, inflammation, CIN1, CIN 2, CIN 3, squamous carcinoma) and later compared to the corresponding histology. Sensitivity and specificity of OCT in detecting cervical dysplasia were determined. Results: OCT images using both OCT systems were taken from 46 sites in ten conisation specimens and later compared to the corresponding histology. CIN lesions were diagnosed correctly by the two-dimensional OCT system with a sensitivity and specificity of 91% and 78% accordingly. Using the three-dimensional system sensitivity and specificity were 82% and 86% accordingly. Conclusions: Both OCT systems used were highly sensitive in identifying cervical intraepithelial neoplasia. Despite technical problems experienced in the present series, we believe that three-dimensional imaging has the potential to further improve the accuracy of optical coherence tomography.


Optical coherence tomography; OCT; Colposcopy; Intraepithelial cervical dysplasia; CIN

Cite and Share

J. Gallwas,R. Gaschler,H. Stepp,K. Friese,C. Dannecker. 3D optical coherence tomography of cervical intraepithelial neoplasia - early experience and some pitfalls. European Journal of Gynaecological Oncology. 2012. 33(1);37-41.


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