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Original Research

Open Access

Could endometrial cytology be helpful in detecting endometrial malignancies ?

  • U. Indraccolo1,*,
  • C. Bracalenti2
  • R. Di Iorio3
  • S.R. Indraccolo3

1Department of Surgical Sciences, University of Foggia, Foggia, Italy

2Department of Clinical Pathology, Operative Unit of Pathology, ASUR 9, Marche, Marche, Italy

3Department of Woman’s Health, Sapienza University, Rome, Italy

DOI: 10.12892/ejgo20120160 Vol.33,Issue 1,January 2012 pp.60-61

Published: 10 January 2012

*Corresponding Author(s): U. Indraccolo E-mail: ugo.indraccolo@libero.it

Abstract

This short communication assesses the concordance indexes between hysteroscopic biopsies and endometrial cytology for each endometrial pattern found in a sample of 37 women. Patients underwent endometrial cytology under sonographic guidance. The specimens were obtained with an endocervical brush and were fixed on slides (no liquid-based methods). After endometrial cytology, hysteroscopy with biopsy was performed. The best concordance index was found for endometrial malignancies, suggesting that endometrial cytology is able to detect cancers but not other endometrial diseases, as compared with endometrial hysteroscopic biopsies. Therefore, the overall concordance index suggests a fair concordance between histological and cytological findings. This leads us to conclude that usual endometrial cytology should not be recommended to screen endometrial diseases, but it may be used as an alternative diagnostic tool when hysteroscopic biopsies or other blinded procedures for endometrial sampling are unwanted, because it allows malignancies to be detected as well as hysteroscopic-guided biopsies.

Keywords

Endometrial cytology; Endometrial biopsy; Diagnosis

Cite and Share

U. Indraccolo,C. Bracalenti,R. Di Iorio,S.R. Indraccolo. Could endometrial cytology be helpful in detecting endometrial malignancies ?. European Journal of Gynaecological Oncology. 2012. 33(1);60-61.

References

[1] Bakour S.H., Jones S.E., O’Donovan P.: “Ambulatory hysteroscopy: evidence-based guide to diagnosis and therapy”. Best Pract. Res. Clin. Obstet. Gynaecol., 2006, 20, 953.

[2] Seamark C.J.: “The demise of the D&C”. JR Soc. Med., 1998, 91, 76.

[3] Clark T.J.: “Outpatient hysteroscopy and ultrasonography in the management of endometrial disease”. Curr. Opin. Obstet. Gynecol., 2004, 16, 305.

[4] Dijkhuizen F.P., Mol B.W., Brölmann H.A., Heintz A.P.: “The accuracy of endometrial sampling in the diagnosis of patients with endometrial carcinoma and hyperplasia: a meta-analysis”. Cancer, 2000, 89, 1765.

[5] Mossa B., Ebano V., Marziani R.: “Reliability of oupatient endometrial brush cytology vs biopsy in postmenopausal symptomatic women”. Eur. J. Gynaecol. Oncol., 2010, 31, 621.

[6] Buccoliero A.M., Gheri C.F., Castiglione F., Garbini F., Barbetti A., Fambrini M. et al.: “Liquid-based endometrial cytology: cytohistological correlation in a population of 917 women”. Cytopathology, 2007, 18, 241.

[7] Kipp B.R., Medeiros F., Campion M.B., Distad T.J., Peterson L.M., Keeney G.L. et al.: “Direct uterine sampling with the Tao brush sampler using a liquid-based preparation method for the detection of endometrial cancer and atypical hyperplasia: a feasibility study”. Cancer, 2008, 114, 228.

[8] Milojkovic M., Hrgovic Z., Maass N., Jonat W., Hrgovic I., Bukovi D. et al.: “Assessnent of reliability endometrial brush cytology in detection etiology of late postmenopausal bleedings”. Arch. Gynecol. Obstet., 2004, 269, 259.

[9] Mathelin C., Youssef C., Annane K., Brettes J.P., Bellocq J.P., Walter P.: “Endometrial brush cytology in the surveillance of postmenopausal patients under tamoxifen: a prospective longitudinal study”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2007, 132, 126.

[10] Landis J.R., Koch G.G.: “The measurement of observer agreement for categorical data”. Biometrics, 1977, 33, 159.

[11] Kovacs G., Hocking G.R., Barnett M.C., Clark J.V.T.: “Endometrial sampling: does combining scraping with suction using the Accurette® device improve efficacy?”. Gynaecol. Endosc., 1998, 7, 315.

[12] Clark T.J., Mann C.H., Shah N., Khan K.S., Song F., Gupta J.K.: “Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review”. BJOG, 2002, 109, 313.

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