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G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature

  • S. Mabuchi1,*,
  • A. Morimoto1
  • M. Fujita1
  • K. Isohashi2
  • T. Kimura1

1Department of Obstetrics and Gynecology, Osaka ,Japan

2Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan

DOI: 10.12892/ejgo201203316 Vol.33,Issue 3,May 2012 pp.316-317

Published: 10 May 2012

*Corresponding Author(s): S. Mabuchi E-mail: smabuchi@gyne.med.osaka-u.ac.jp

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Abstract

We describe a case of FIGO Stage IB2 uterine cervical cancer which showed focal intense bone marrow FDG uptake mimicking bone metastases after the administration of G-CSF. This case highlights the importance of avoiding the administration of G-CSF prior to PET imaging.

Keywords

G-CSF; FDG PET/CT; Cervical cancer; Bone metastasis

Cite and Share

S. Mabuchi,A. Morimoto,M. Fujita,K. Isohashi,T. Kimura. G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature. European Journal of Gynaecological Oncology. 2012. 33(3);316-317.

URL:

https://www.ejgo.net/articles/10.12892/ejgo201203316

References

[1] Sugawara Y., Fisher S.J., Zasadny K.R., Kison P.V., Baker L.H., Wahl R.L.: “Preclinical and clinical studies of bone marrow uptake of fluorine-1-fluorodeoxyglucose with or without granulocyte colony-stimulating factor during chemotherapy”. J. Clin. Oncol., 1998, 16, 173.

[2] Kazama T., Swanston N., Podoloff D.A., Macapinlac H.A.: “Effect of colony-stimulating factor and conventional- or high-dose chemotherapy on FDG uptake in bone marrow”. Eur. J. Nucl. Med. Mol. Imaging, 2005, 32, 1406.

[3] Basu S., Torigian D., Alavi A.: “Evolving concept of imaging bone marrow metastasis in the twenty-first century: critical role of FDGPET”. Eur. J. Nucl. Med. Mol. Imaging, 2008, 35, 465.

[4] Nakamoto Y., Suga T., Hara T., Ishizu K., Togashi K.: “Inhomogeneous bone marrow uptake caused by G-CSF mimics multiple bone metastases on FDG-PET”. Clin. Nucl. Med., 2010, 35, 74.

[5] Kouba M., Maaloufova J., Campr V., Belohlavek O., Drugova B.: “G-CSF stimulated islands of haematopoiesis mimicking disseminated malignancy on PET-CT and MRI scans in a patient with hypoplastic marrow disorder”. Br. J. Haematol., 2005, 130, 807.

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