Article Data

  • Views 425
  • Dowloads 111

Original Research

Open Access

“Intestinal-type” mucinous adenocarcinoma of the vulva: a report of two cases

  • G. Cormio1
  • C. Carriero1
  • V. Loizzi1,*,
  • F. Gissi1
  • L. Leone1
  • G. Putignano1
  • L. Resta2
  • L. Selvaggi1

1Department of Gynecology, Gynecologic Oncology Unit, Obstetrics and Neonatology (DIGON), Bari, Italy

2Department of Pathology, University of Bari, Bari, Italy

DOI: 10.12892/ejgo201204433 Vol.33,Issue 4,July 2012 pp.433-435

Published: 10 July 2012

*Corresponding Author(s): V. Loizzi E-mail: vloizzi@tiscali.it

Abstract

Background: "Intestinal-type" mucinous carcinoma of the vulva is extremely rare with very few cases reported in the literature. Case report: The authors report two patients who had diagnosis of intestinal-type mucinous adenocarcinoma of the vulva after excisional biopsy. In both cases, restaging was perfomed with total body computed tomography (CT) scan, gastroscopy, and colonoscopy that showed no other site of disease. A radical vulvectomy with bilateral systematic inguinal lymphadenectomy was performed, and in both cases no residual disease was found. A patient developed metastatic (liver, bone marrow) colonic cancer 36 months after primary surgery, received multiple lines of chemotherapy, and died of disseminated disease 18 months after diagnosis. The other patient was found to have dysplastic polyp in the sigmoid colon, and is alive without disease at 39 months after primary diagnosis. Conclusion: Intestinal-type mucinous carcinoma of the vulva has a poor prognosis. Strict endoscopic follow-up of the colon is mandatory in such cases, considering the high propensity of associated gastrointestinal (GI) tumors.

Keywords

Adenocarcinoma of the vulva; Intestinal-type

Cite and Share

G. Cormio,C. Carriero,V. Loizzi,F. Gissi,L. Leone,G. Putignano,L. Resta,L. Selvaggi. “Intestinal-type” mucinous adenocarcinoma of the vulva: a report of two cases. European Journal of Gynaecological Oncology. 2012. 33(4);433-435.

References

[1] Ghamande S.A., Kasznica J., Griffiths T., Finkler N.J., Hamid A.M.: “Mucinous adenocarcinomas of the vulva”. Gynecol. Oncol., 1995, 57, 117.

[2] Kennedy J.C., Majmudar B.: “Primary adenocarcinoma of the vulva, possibly cloacogenic. A report of two cases”. J. Reprod. Med., 1993, 38, 113.

[3] Nasir S., Zaidi H., Conner M.C.: “Primary vulvar adenocarcinoma of cloacogenic origin”. South Med. J., 2001, 94, 744.

[4] Tiltman A.J., Knutzen V.K.: “Primary adenocarcinoma of the vulva originating in misplaced cloacal tissue”. Obstet. Gynecol., 1978, 51, 30s.

[5] Wille´n R., Be´ka´ssy Z., Carle´n B., Bozoky B., Cajander S.: “Cloacogenic adenocarcinoma of the vulva”. Gynecol. Oncol., 1999, 74, 298.

[6] Wilkinson E.J.: “Premalignant and malignant tumors of the vulva”. In: Kurman R.J. (ed.): Blaustein’s Pathology of the Female Genital Tract. 5th edition. New York, Springer-Verlag, 2002, 122.

[7] Rodriguez A., Isaac M.A., Hidalgo E., Marquez B., Nogales F.F.: “Villoglandular adenocarcinoma of the vulva”. Gynecol. Oncol., 2001, 83, 409.

[8] Frierson H.F., Mills S.E.: “The vulva and vagina”. In: Sternberg S.S., Antonioli D.A., Carter D. et al. (eds.), Diagnostic Surgical Pathology, 3rd edition. Philadelphia, Lippincott Williams and Wilkins, 1999, 2129.

[9] Novak E.R., Woodruff J.D.: “Gynecologic and Obstetric Pathology With Clinical and Endocrine Relations”. 7th edition. Philadelphia, Saunders, 1974, 26.

[10] Loy T.S., Caladuce R.D., Keeney G.L.: “Cytokeratin immunostaining in differentiating primary ovarian carcinoma from metastatic colonic adenocarcinoma”. Mod. Pathol., 1996, 9, 1040.

[11] Dube V., Veilleux C., Plante M., Tetu B.: “Primary villoglandular adenocarcinoma of cloacogenic origin of the vulva”. Hum. Pathol., 2004, 35, 377.

[12] Hsu S.M., Raine L., Fanger H.: “Use of avidin-biotin-peroxydase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabeled antibody (PAP) procedures”. J. Histochem. Cytochem, 1981, 29, 577.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top