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Original Research

Open Access

Evaluation of primary prophylaxis with granulocyte colony-stimulating factor for epithelial ovarian cancer

  • K. Matsui1
  • T. Mori1,*,
  • M. Sawada1
  • H. Kuroboshi1
  • H. Tatsumi1
  • T. Yoshioka1
  • M. Akiyama1
  • T. Yamamoto1
  • K. Iwasaku1
  • J. Kitawaki1

1Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto (Japan)

DOI: 10.12892/ejgo23932014 Vol.35,Issue 1,January 2014 pp.48-51

Published: 10 January 2014

*Corresponding Author(s): T. Mori E-mail:


Purpose: Primary prophylaxis with G-CSF has been used to minimize myelosuppression caused by anticancer agents and to avoid severe neutropenia. The authors retrospectively examined the value of primary prophylaxis using granulocyte colony-stimulating factor (G-CSF) for epithelial ovarian cancer. Materials and Methods: From 2001 to 2010, 105 patients with ovarian cancer receiving chemotherapy in the present hospital were divided into two groups: one received primary prophylaxis with G-CSF and the other did not receive it in compliance with the guidelines for G- CSF usage. The incidence of febrile neutropenia (FN), degree of neutropenia, frequency of G-CSF administration, number of days of hospitalization, progression-free survival (PFS), and overall survival (OS) were evaluated. Results: Neutrophils decreased almost equally and the length of hospitalization was not significantly lower between the groups. Five-year PFS or OS showed no significant difference either. Conclusions: Primary prophylaxis with G-CSF in chemotherapy for epithelial ovarian cancer could be of low significance.


Epithelial ovarian cancer; Primary prophylaxis; Granulocyte colony-stimulating factor; Febrile neutropenia.

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K. Matsui,T. Mori,M. Sawada,H. Kuroboshi,H. Tatsumi,T. Yoshioka,M. Akiyama,T. Yamamoto,K. Iwasaku,J. Kitawaki. Evaluation of primary prophylaxis with granulocyte colony-stimulating factor for epithelial ovarian cancer. European Journal of Gynaecological Oncology. 2014. 35(1);48-51.


[1] Bodey G.P., Buckley M., Monica B., Sathe Y.S.: “Quantitative Relationships Between Circulating Leukocytes and Infection Patients with Acute Leukemia”. Ann. Intern. Med., 1966, 64, 328.

[2] Official Journal of the Japan Society of Clinical Oncology: “G- CSF guideline for an appropriate usage”. Int. J. Clin. Oncol., 2001, 6, 1.

[3] Thomas J.S., James K., Lyman G.H., Howard O., James O.A., Lodovico B. et al.: “2006 Update of Recommendations for the Use of White Blood Cell Growth Factors: An Evidence-Based Clinical Practice Guideline”. J. Clin. Oncol., 2006, 24, 3187.

[4] Masaoka T.: “Conclusions and recommendations: Evidence-based recommendations for antimicrobial use in febrile neutropenia in Japan”. Int. J. Hematol., 1998, 68, S39.

[5] Vital Statistics Japan (Ministry of Health. Labor and Welfare): Center for Cancer Control and Information Services, National Cancer Center, Japan, 2006. Updated January 27, 2011.

[6] Heintz A.P., Odicino F., Maisonneuve P.: “Carcinoma of the Ovary”. Int. J. Gynecol. Obstets., 2003, 83, 135.

[7] Crawford J., Howard O., Ronald S., David J., Gary L., Imad T. et al.: “Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small cell lung cancer”. N. Engl. J. Med., 1991, 523, 164.

[8] Ruth P., Howard G., John A.R., David P.D., Roger J., Peter M.W. et al.: “Granulocyte Colony-Stimulating Factor to Prevent Dose-Limiting Neutropenia in Non-Hodgkin’s Lymphoma”. Blood, 1992, 80, 1430.

[9] Kuderer N.M., Dale D.C., Crawford J., Lyman G.H.: “Impact of Primary Prophylaxis With Granulocyte Colony-Stimulating Factor on Febrile Neutropenia and Mortality in Adult Cancer Patients Receiving Chemotherapy”. J. Clin. Oncol., 2007, 25, 3158.

[10] Jean K., Marianne P., Edward B.R., Michael B., Linda E., Ronald F. et al.: “The Multinational Association of Supportive Care in Cancer Risk Index.A Multinational Scoring System for Identifying Low-Risk Febrile Neutropenic Cancer Patients”. J. Clin. Oncol., 2000, 18, 3038.

[11] Jean K., Marianne P., Asoasia G., Frederique M., Barbara P., Laurent D. et al.: “Outpatient Oral Antibiotics for Febrile Neutropenic Cancer Patients Using a Predictive for Complications”. J. Clin. Oncol., 2006, 24, 4129.

[12] Tamura K.: “Initial empirical antimicrobial therapy: Duration and Subsequent Modefications”. Clin. Infect. Dis., 2004, 39, 59.

[13] Walter T.H., Donald A., Gerald P.B., Eric J.B., Arthur E.B., Thierry C. et al.: “2002 Guidelines for the Use Antimicrobial Agents in Neutropenic Patients with Cancer”. Clin. Infect. Dis., 2002, 34, 730.

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