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Original Research

Open Access

Comparison of whole-body PET/PET-CT and conventional imaging procedures for distant metastasis staging in patients with breast cancer: a meta-analysis

  • Zhe Sun1
  • Yu Li Yi2
  • Yu Liu2
  • Jian Ping Xiong1
  • Chao Zhu He2,*,

1Oncology Department, The First Affiliated Hospital of Nanchang University, Nanchang, China

2Nursing College of Nanchang University, Nanchang, China

DOI: 10.12892/ejgo2412.2015 Vol.36,Issue 6,December 2015 pp.672-676

Published: 10 December 2015

*Corresponding Author(s): Chao Zhu He E-mail: chaozhu_he@163.com

Abstract

Aim: To compare the performance of whole-body PET/PET-CT with that of conventional imaging procedures for the overall assessment of distant metastasis in patients with breast cancer. Materials and Methods: The authors performed a meta-analysis of all available studies of whole-body PET/PET-CT compared with conventional imaging procedures. They calculated sensitivities, specificities, positive likelihood ratios, negative likelihood ratios, and constructed summary receiver operating characteristic (ROC) curves using bivariate regression models for whole-body PET/PET-CT and conventional imaging procedures, respectively. Results: Across six studies (609 patients), sensitivity, specificity, positive likelihood ratios, and negative likelihood ratios of whole-body PET/PET-CT were 0.99 (95% confidence interval [CI] = 0.88–1.00), 0.95 (95% CI = 0.89–0.98), 21.1 (95% CI = 8.2–55.5), and 0.02 (95% CI = 0.001–0.13), respectively, and of conventional imaging procedures they were 0.57 (95% CI = 0.37–0.74), 0.88 (95% CI = 0.78–0.94), 4.8 (95% CI = 2.8–8.2) and 0.49 (95% CI = 0.33–0.74), respectively. Conclusion: Compared with conventional imaging procedures, whole-body PET/PET-CT had excellent diagnostic performance for distant metastasis staging in patients with breast cancer.

Keywords

PET; Breast cancer; Distant metastasis; Meta-analysis.

Cite and Share

Zhe Sun,Yu Li Yi,Yu Liu,Jian Ping Xiong,Chao Zhu He. Comparison of whole-body PET/PET-CT and conventional imaging procedures for distant metastasis staging in patients with breast cancer: a meta-analysis. European Journal of Gynaecological Oncology. 2015. 36(6);672-676.

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