The correspondence between abnormal transformation zone Grade 1 and Grade 2 colposcopic parameters and histology. Clinical implications.

Objective: To analyse the correlation between the colposcopic parameters of Grade 1 and Grade 2 abnormal transformation zone (ANTZ G1-ANTZ G2) and histological examination of the cone. Materials and Methods: A retrospective analysis of medical records of 600 women woho underwent colposcpy and conisation (large loop excision of the transformation zone - LLETZ) between January 1, 2009 and July 31, 2012. The correlation between colposcopic and histological parameters was analysed using the Spearman non- parametric test. Results: In ANTZG1 there was no correlation (r= - 0.03; p = 0.55); in ANTZG2 however, a low degree of correlation (r = 0.21; p = 0.03) was found. Sensitivity, specificity, and positive and negative predictive values of an ANTZ G2 colposcopic picture were 33.45% (confidence interval [CI] 95% 28.0% to 39.2%), 95.48% (CI 95% 92.5% to 97.5%), 87.4% (CI 95% 79.7% to 92.9%), and 60.5% (CI 95% 56% to 64.9%), respectively. Conclusions: The decisive factor in the diagnosis of the cervical oncologic pathologies is the histological examination of the cone, and not the colposcopy which should be seen as a “guiding” investigation in predicting conisation and application of the most appropriate treatment.

Colposcopy; CIN; Biopsy; Conisation; LLETZ; HPV.

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