Article Data

  • Views 484
  • Dowloads 143

Case Reports

Open Access

Granular cells tumor of the vulva: an exceptional entity

  • I. Brunel1,*,
  • E. Moreno-Palacios1
  • J. De Santiago1
  • I. Zapardiel1

1Gynecological Oncology Unit, La Paz University Hospital, Madrid, Spain

DOI: 10.12892/ejgo2665.2015 Vol.36,Issue 5,October 2015 pp.605-606

Published: 10 October 2015

*Corresponding Author(s): I. Brunel E-mail: ibrunelg@gmail.com

Abstract

Introduction: Granular cells tumor (GCT) is a rare tumor that develops on skin and soft tissues. Only 1-2% of these tumors present malignant behavior. Material and methods: The authors report three cases of GCT and review the management of these tumors. Case report: The first case is a 73-year-old woman who was diagnosed with an atypical GCT. She was treated with local excision and then presented a local recurrence 21 months after the surgery. The other two cases are 60- and 58-year-old women diagnosed with a benign GCT. They were treated with single excision; both patients underwent second surgery due to margin affectation. Conclusions: Management of GCT is not clear nowadays. The careful selection of patients with poor prognostic factors is very important. Follow-up for early diagnosis of local recurrence and metastases of these tumors is of utmost importance.

Keywords

Vulvar cancer; Granular cells tumor; S-100 protein.

Cite and Share

I. Brunel,E. Moreno-Palacios,J. De Santiago,I. Zapardiel. Granular cells tumor of the vulva: an exceptional entity. European Journal of Gynaecological Oncology. 2015. 36(5);605-606.

References

[1] Horowitz I.,R., Copas P., Majmudar B.: “Granular cell tumors of the vulva”. Am. J. Obstet. Gynecol., 1995, 173, 1710.

[2] Ordóñez N.G., Mackay B.: “Granular cell tumor: a review of the pathology and histogenesis”. Ultrastruct. Pathol., 1999, 23, 207.

[3] Lack E.E., Worsham G.F., Callihan M.D., Crawford B.E., Klappenbach S., Rowden G., et al.: “Granular cell tumor: a clinicopathologic study of 110 patients”. J. Surg. Oncol., 1980, 13, 301.

[4] Fanburg-Smith J.C., Meis-Kindblom J.M., Fante R., Kindblom L.G.: “Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation”. Am. J. Surg. Pathol., 1998, 22, 779.

[5] Janousková G., Campr V., Konkol’ová R., Zemanová R., Hoch J., Hercogová J.: “Multiple granular cell tumour”. J. Eur. Acad. Dermatol. Venereol., 2004, 18, 347.

[6] Schmidt O., Fleckenstein G.H., Gunawan B., Füzesi L., Emons G.: “Recurrence and rapid metastasis formation of a granular cell tumor of the vulva”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2003, 106, 219.

[7] Miracco C, Andreassi A, Laurini L, De Santi MM, Taddeucci P, Tosi P.: “Granular cell tumour with histological signs of malignancy: report of a case and comparison with 10 benign and 4 atypical cases”. Br. J. Dermatol., 1999, 141, 573.

[8] Ramos P.C., Kapp D.S., Longacre T.A., Teng N.N.: “Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review”. Int. J. Gynecol. Cancer., 2000, 10, 429.

[9] Steffansson K, Wollmann RL.: “S100 protein in granular cell tumors”. Cancer., 1982, 49, 1834.

[10] Robertson A.J., McIntosh W., Lamont P., Guthrie W.: “Malignant granular cell tumor (myoblastoma) of the vulva: report of a case and review of the literatura”. Histopathology., 1981, 5, 69.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top