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Case Reports

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Granular cells tumor of the vulva: an exceptional entity

  • I. Brunel1,*,
  • E. Moreno-Palacios1
  • J. De Santiago1
  • I. Zapardiel1

1Gynecological Oncology Unit, La Paz University Hospital, Madrid, Spain

DOI: 10.12892/ejgo2665.2015 Vol.36,Issue 5,October 2015 pp.605-606

Published: 10 October 2015

*Corresponding Author(s): I. Brunel E-mail: ibrunelg@gmail.com

Abstract

Introduction: Granular cells tumor (GCT) is a rare tumor that develops on skin and soft tissues. Only 1-2% of these tumors present malignant behavior. Material and methods: The authors report three cases of GCT and review the management of these tumors. Case report: The first case is a 73-year-old woman who was diagnosed with an atypical GCT. She was treated with local excision and then presented a local recurrence 21 months after the surgery. The other two cases are 60- and 58-year-old women diagnosed with a benign GCT. They were treated with single excision; both patients underwent second surgery due to margin affectation. Conclusions: Management of GCT is not clear nowadays. The careful selection of patients with poor prognostic factors is very important. Follow-up for early diagnosis of local recurrence and metastases of these tumors is of utmost importance.

Keywords

Vulvar cancer; Granular cells tumor; S-100 protein.

Cite and Share

I. Brunel,E. Moreno-Palacios,J. De Santiago,I. Zapardiel. Granular cells tumor of the vulva: an exceptional entity. European Journal of Gynaecological Oncology. 2015. 36(5);605-606.

References

[1] Horowitz I.,R., Copas P., Majmudar B.: “Granular cell tumors of the vulva”. Am. J. Obstet. Gynecol., 1995, 173, 1710.

[2] Ordóñez N.G., Mackay B.: “Granular cell tumor: a review of the pathology and histogenesis”. Ultrastruct. Pathol., 1999, 23, 207.

[3] Lack E.E., Worsham G.F., Callihan M.D., Crawford B.E., Klappenbach S., Rowden G., et al.: “Granular cell tumor: a clinicopathologic study of 110 patients”. J. Surg. Oncol., 1980, 13, 301.

[4] Fanburg-Smith J.C., Meis-Kindblom J.M., Fante R., Kindblom L.G.: “Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation”. Am. J. Surg. Pathol., 1998, 22, 779.

[5] Janousková G., Campr V., Konkol’ová R., Zemanová R., Hoch J., Hercogová J.: “Multiple granular cell tumour”. J. Eur. Acad. Dermatol. Venereol., 2004, 18, 347.

[6] Schmidt O., Fleckenstein G.H., Gunawan B., Füzesi L., Emons G.: “Recurrence and rapid metastasis formation of a granular cell tumor of the vulva”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2003, 106, 219.

[7] Miracco C, Andreassi A, Laurini L, De Santi MM, Taddeucci P, Tosi P.: “Granular cell tumour with histological signs of malignancy: report of a case and comparison with 10 benign and 4 atypical cases”. Br. J. Dermatol., 1999, 141, 573.

[8] Ramos P.C., Kapp D.S., Longacre T.A., Teng N.N.: “Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review”. Int. J. Gynecol. Cancer., 2000, 10, 429.

[9] Steffansson K, Wollmann RL.: “S100 protein in granular cell tumors”. Cancer., 1982, 49, 1834.

[10] Robertson A.J., McIntosh W., Lamont P., Guthrie W.: “Malignant granular cell tumor (myoblastoma) of the vulva: report of a case and review of the literatura”. Histopathology., 1981, 5, 69.

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