Can the histopathology influence the outcome of early-stage cervical cancer?

Purpose of investigation: The assessment of the histology influence on survival in early-stage cervical cancer patients treated with surgery. Materials and Methods: The retrospective analysis of 71 cervical adenocarcinoma (AC), International Federation of Gynecology and Obstetrics (FIGO) Stage IB, treated initially with surgery, between 1989 and 1999 and 43 squamous cell cancer (SCC) patients, treated with the same method, between 1998 and 1999, was performed. Cox multi-variant analysis and the Kaplan-Meyer methods were performed (the level of statistical significance, p ≤ 0.05). Results: The ten-year overall survival (OS) of AC and SCC patients was 67.5% and 90%, p = 0.015. The ten-year disease free survival (DFS) was 63% and 85%, p = 0.022, respectively. After adjusting the significant prognostic factors, patients with AC had significantly worse treatment outcomes than patients with SCC: DFS (relative risk (RR)1.85, 95% CI = 1.28-2.69, p = 0.001) and OS (RR 1.65, 95% CI = 1.65-2.33, p = 0.005). Conclusion: Prognosis of early cervical AC patients, treated with surgery, appears to be less favorable as compared to patients with SCC, treated with the same method.

Cervical cancer; Adenocarcinoma; Squamous cell cancer; Radiotherapy; Surgery; Treatment outcomes.

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