Article Data

  • Views 498
  • Dowloads 146

Case Reports

Open Access

Ovarian large cell neuroendocrine carcinoma in the youngest woman

  • Y.S. Kwon1
  • K.S. Im2,*,
  • D.I. Choi2

1Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Ulsan University Hospital, Ulsan, Korea

2Department of Anesthesiology and Pain Medicine, Uijeongbu St Mary's Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Korea

DOI: 10.12892/ejgo2801.2016 Vol.37,Issue 2,April 2016 pp.244-246

Published: 10 April 2016

*Corresponding Author(s): K.S. Im E-mail:


Large cell neuroendocrine carcinoma (LCNC) of the ovary is a rare tumor in gynecologic oncologic field. An 18-year-old woman presented with abdominal distention and a pelvic mass measuring ten cm in diameter, who previously underwent laparoscopic ovarian cystectomy due to large borderline mucinous ovarian neoplasm 18 months prior. A debulking operation was optimally performed, which included total abdominal hysterectomy with bilateral salpingo-oophorectomy, bilateral pelvic lymph node dissection, bilateral paraaortic lymph node dissection, omentectomy, optimal debulking of gastrohepatic mass and subdiaphragmatic mass, and pelvic peritonectomy. Despite adjuvant chemotherapy with paclitaxel and carboplatin, the patient died of progressive disease seven months after surgery. The authors report the youngest case of LCNC of the ovary, that failed chemotherapy and had the previous history of the conservative surgical treatment due to mucinous borderline tumor.


Large cell neuroendocrine carcinoma; Ovary; Rare tumor.

Cite and Share

Y.S. Kwon,K.S. Im,D.I. Choi. Ovarian large cell neuroendocrine carcinoma in the youngest woman. European Journal of Gynaecological Oncology. 2016. 37(2);244-246.


[1] Roth L.M., Tsubura A., Dietel M., Senzaki H.: “Miscellaneous tumours and tumour-like conditions of the ovary”. In: Tavassoli F.A., Devilee P., (eds). Pathology and Genetics of Tumours of the Breast and Female Genital Organs. World Health Organization Classification of Tumours. Lyon, France: International Agency for Research on Cancer, 2003, 182.

[2] Collins R.J., Cheung A., Ngan H.Y., Wong L.C., Chan S.Y., Ma H. K.: “Primary mixed neuroendocrine and mucinous carcinoma of the ovary”. Arch. Gynecol. Obstet., 1991, 248, 139.

[3] Choi Y.D., Lee J.S., Choi C., Park C.S., Nam J.H.: “Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma”. Gynecol. Oncol., 2007, 104, 747.

[4] Chen K.T.: “Composite large-cell neuroendocrine carcinoma and surface epithelial-stromal neoplasm of the ovary”. Int. J. Surg. Pathol., 2000, 8, 169.

[5] Eichhorn J.H., Lawrence W.D., Young R.H., Scully R.E.: “Ovarian neuroendocrine carcinomas of non-small cell type associated with surface epithelial adenocarcinomas. A study of five cases and review of the literature”. Int. J. Gynecol. Pathol., 1996, 15, 303.

[6] Veras E., Deavers M.T., Silva E.G., Malpica A.: “Ovarian nonsmall cell neuroendocrine carcinoma. A clinicopathologic and immunohistochemical study of 11 cases”. Am. J. Surg. Pathol., 2007, 31, 774.

[7] Khurana K., Tornos C., Silva E.: “Ovarian neuroendocrine carci-noma associated with mucinous neoplasm”. Arch. Pathol. Lab. Med., 1994, 118, 1032.

[8] Jones K., Diaz J.A., Donner L.R.: “Neuroendocrine carcinoma arising in an ovarian mucinous cystadenoma”. Int. J. Gynecol. Pathol., 1996, 15, 167.

[9] Ohira S., Itoh K., Shiozawa T., Horiuchi A., Ono K., Takeuchi H., et al.: “Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone- related hypercalcemia”. Int. J. Gynecol. Pathol., 2004, 23, 393.

[10] Hirasawa T.: “Ovarian neuroendocrine carcinoma associated with mucinous carcinoma and teratoma”. Nippon. Rinsho., 2004, 62, 973.

[11] Ahmed Z., Aftab K., Kayani N.: “Ovarian primary neuroendocrine carcinoma of non-small cell type: report of an extremely rare neoplasm”. J. Pak. Med. Assoc., 2005, 55, 82.

[12] Draganova-Tacheva R.A., Khurana J.S., Huang Y., Hernandez E., Zhang X.: “Large cell neuroendocrine carcinoma of the ovary associated with serous carcinoma with mucin production: a case report and literature review”. Int. J. Clin. Exp. Pathol., 2009, 2, 304.

[13] Yasuoka H., Tsujimoto M., Fujita S., Kunishige I., Nishio Y., Kodama R., et al.: “Monoclonality of composite large cell neuroendocrine carcinoma and mucinous epithelial tumor of the ovary: a case study”. Int. J. Gynecol. Pathol., 2009, 28, 55.

[14] Tsuji T., Togami S., Shintomo N., Fukamachi N., Douchi T., Taguchi S.: “Ovarian large cell neuroendocrine carcinoma”. J. Obstet. Gynaecol. Res. 2008, 34, 726.

[15] Chênevert J., Bessette P., Plante M., Têtu B., Dubé V.: “Mixed ovarian large cell neuroendocrine carcinoma, mucinous adenocarcinoma, and teratoma: a report of two cases and review of the literature”. Pathol. Res. Pract., 2009, 205, 657.

[16] Behnam K., Kabus D., Behnam M.: “Primary ovarian undifferentiated non-small cell carcinoma, neuroendocrine type”. Gynecol. Oncol., 2004, 92, 372.

[17] Dundr P., Fischerová D., Povýsil C., Cibula D.: “Primary pure largecell neuroendocrine carcinoma of the ovary”. Pathol. Res. Pract., 2008, 204, 133.

[18] Lindboe C.F.: “Large cell neuroendocrine carcinoma of the ovary”. APMIS, 2007, 115, 169.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time