Article Data

  • Views 446
  • Dowloads 120

Case Reports

Open Access

Schwannomas of female genitalia from a gynaecologist’s perspective: report of two cases and review of the literature

  • S. Jiang1,2,3
  • Q.S. Li1,2,3
  • X.G. Sheng1,2,3,*,
  • Q.Q. Song1,3
  • C.H. Lu1,2,3
  • C.X. Pan1,3

1Department of Gynecologic Oncology, Shandong Cancer Hospital and Institute, Jinan City, China

2Department of Gynecologic Oncology, Shandong Academy of Medical Science, Jinan City, China

3Cancer Prevention and Research Institute of Shandong Province, Jinan City, China

DOI: 10.12892/ejgo2805.2016 Vol.37,Issue 2,April 2016 pp.254-257

Published: 10 April 2016

*Corresponding Author(s): X.G. Sheng E-mail: shengxiugui@163.com

Abstract

Background: Pelvic schwannomas are extremely rare. However, when located in the pelvic cavity, schwannomas are often encountered by a gynaecologist, not a general surgeon, and are misdiagnosed as gynaecologic masses. Case Report: Here, the authors present two cases of pelvic schwannomas that were preoperatively misdiagnosed as broad ligament fibroid. One schwannoma occurred completely in the left broad ligament and was resected by laparoscopy without any complications. The other lesion was located in the retroperitoneum and had densely adhered to the surrounding tissues; this lesion was excised by laparotomy with considerable blood loss. Conclusions: Schwannomas of female genitalia are very scarce and difficulty to diagnose preoperatively. Literature review revealed 63 schwannomas arising from the female genital tract in total, 73.02% (46 cases) were located in the lower genital tract, and 26.98% (17 cases) were located in upper genital tract. The treatment modality is unique depending on the location of the tumor. Complete excision is benefical for diagnosis and treatment. The procedure can be performed safely under laparoscopy.

Keywords

Neurilemmoma; Laparoscopy; Pelvic neoplasms; Genital neoplasms; Female.

Cite and Share

S. Jiang,Q.S. Li,X.G. Sheng,Q.Q. Song,C.H. Lu,C.X. Pan. Schwannomas of female genitalia from a gynaecologist’s perspective: report of two cases and review of the literature. European Journal of Gynaecological Oncology. 2016. 37(2);254-257.

References

[1] Masson P.: “Experimental and Spontaneous Schwannomas (Peripheral Gliomas): I. Experimental Schwannomas”. Am. J. Pathol., 1932, 8, 367.

[2] Masson P.: “Experimental and Spontaneous Schwannomas (Peripheral Gliomas): II. Spontaneous schwannomas”. Am. J. Pathol., 1932, 8, 389.

[3] Daneshmand S., Youssefzadeh D., Chamie K., Boswell W., Wu N., Stein J.P., et al.: “Benign retroperitoneal schwannoma: a case series and review of the literature”. Urology, 2003, 62, 993.

[4] Takeuchi M., Matsuzaki K., Nishitani H.,Uehara H.: “Ancient schwannoma of the female pelvis”. Abdom. Imaging, 2008, 33, 247.

[5] Borghese M., Corigliano N., Gabriele R., Antoniozzi A., Izzo L., Barbaro M., et al.: “Benign schwannoma of the pelvic retroperitoneum. Report of a case and review of the literature”. G. Chir., 2000, 21, 232.

[6] Yadav Y., Onon T.,Sukumar S.: “Conservative management of a pelvic Schwannoma presenting as an adnexal mass”. J. Obstet. Gynaecol., 2008, 28, 364.

[7] Denes F.T., Borelli M., Toledo V.P.,de Goes G.M.: “Pelvic neurilemmoma”. Int. Urol. Nephrol., 1978, 10, 279.

[8] Agaram N.P., Prakash S.,Antonescu C.R.: “Deep-seated plexiform schwannoma: a pathologic study of 16 cases and comparative analysis with the superficial variety”. Am. J. Surg. Pathol., 2005, 29, 1042.

[9] Santos L.D., Currie B.G.,Killingsworth M.C.: “Case report: plexiform schwannoma of the vulva”. Pathology, 2001, 33, 526.

[10] Woodruff J.M., Marshall M.L., Godwin T.A., Funkhouser J.W., Thompson N.J.,Erlandson R.A.: “Plexiform (multinodular) schwannoma. A tumor simulating the plexiform neurofibroma”. Am. J. Surg. Pathol.,1983, 7, 691.

[11] Torres Lobaton A., Cruz Ortiz H., Rojo Herrera G.,Avila Medrano L.: “Sarcomas of the vulva. Report of 2 cases”. Ginecol. Obstet . Mex., 2000, 68, 429.

[12] Hanafy A., Lee R.M.,Peterson C.M.: “Schwannoma presenting as a Bartholin's gland abscess”. Aust. N. Z. J. Obstet. Gynaecol., 1997, 37, 483.

[13] Bozkurt M.,Kara D.: “Giant vulvar schwannoma: a case report”. Acta Med. Iran., 2013, 51, 427.

[14] Bryan W.E.: “Neurilemmoma of the vulva”. J. Obstet. Gynaecol. Br. Emp., 1955, 62, 949.

[15] Tahmasbi M., Nguyen J., Ghayouri M., Shan Y.,Hakam A.: “Primary uterine cervix schwannoma: a case report and review of the literature”. Case Rep. Pathol., 2012, 2012, 353049.

[16] Gwavava N.J.,Traub A.I.: “A neurilemmoma of the cervix”. Br. J. Obstet. Gynaecol., 1980, 87, 444.

[17] Cid J.M.: “Schwannosis of the endocervix. New ideas on old matters”. An Cir (Rosario), 1960, 25, 162.

[18] Azurah A.G., Grover S.,McGregor D.: “Plexiform schwannoma of the clitoris in a young girl: a case report”. J. Reprod. Med., 2013, 58, 365.

[19] Yegane R.A., Alaee M.S.,Khanicheh E.: “Congenital plexiform schwannoma of the clitoris”. Saudi Med. J., 2008, 29, 600.

[20] Chuang W.Y., Yeh C.J., Jung S.M.,Hsueh S.: “Plexiform schwannoma of the clitoris”. APMIS, 2007, 115, 889.

[21] Thomas W.J., Bevan H.E., Hooper D.G.,Downey E.J.: “Malignant schwannoma of the clitoris in a 1-year-old child”. Cancer, 1989, 63, 2216.

[22] Ellison D.W., MacKenzie I.Z.,McGee J.O.: “Cellular schwannoma of the vagina”. Gynecol. Oncol., 1992, 46, 119.

[23] Inoue T., Kato H., Yoshikawa K., Adachi T., Etoh K.,Wake N.: “Retroperitoneal schwannoma bearing at the right vaginal wall”. J. Obstet. Gynaecol. Res., 2004, 30, 454.

[24] Gruhn J.G., Hughes J.C.,Aldisert C.O.: “Tumors of the peripheral nervous system of gynecologic interest: report of a case of a neurilemmoma within the right broad ligament mimicking an ovarian cyst”. Am. J. Obstet. Gynecol., 1959, 78, 1334.

[25] Sinha R., Sundaram M., Hegde A.,Mahajan C.: “Pelvic schwannoma masquerading as broad ligament myoma”. J. Minim. Invasive Gynecol., 2008, 15, 217.

[26] Laszlo A., Ivaskevics K.,Sapi Z.: “Malignant epithelioid ovarian schwannoma: a case report”. Int. J. Gynecol. Cancer, 2006, 16, 360.

[27] Schuppler U., Weisner D., Schollmeyer T., Luttges J.,Kovacs G.: “Imitation of ovarian malignant tumor by malignant schwannoma”. Geburtshilfe Frauenheilkd., 1995, 55, 110.

[28] Stone G.C., Bell D.A., Fuller A., Dickersin G.R.,Scully R.E.: “Malignant schwannoma of the ovary. Report of a case”. Cancer, 1986, 58, 1575.

[29] Anev I., Clarke A., Lee-Elliott C.,Carpenter T.: “Rare case of schwannoma in the rectovaginal septum”. Gynecol. Surg., 2011, 8, 367.

[30] Gronbaek P.: “Two neurinomas of the stomach and a neurinoma of the rectovaginal septum”. Ugeskr. Laeger., 1952, 114, 246.

[31] Schut N.: “A neurilemmoma (schwannoma) in the rectovaginal septum”. Bull. Soc. R. Belge. Gynecol. Obstet., 1961, 31, 381.

[32] Ueda M., Okamoto Y.,Ueki M.: “A pelvic retroperitoneal schwannoma arising in the right paracolpium”. Gynecol. Oncol., 1996, 60, 480.

[33] Cowles T.,Schwartz P.E.: “A suprapubic retroperitoneal operative approach to solitary paravaginal tumors”. Obstet. Gynecol., 1987, 69, 420.

[34] Machairiotis N., Zarogoulidis P., Stylianaki A., Karatrasoglou E., Sotiropoulou G., Floreskou A., et al.: “Pelvic schwannoma in the right parametrium”. Int. J. Gen. Med., 2013, 6, 123.

[35] Duran B., Guvenal T., Yildiz E., Cetin M., Erden O.,Demirkoprulu N.: “An unusual cause of adnexal mass: fallopian tube schwannoma”. Gynecol. Oncol., 2004, 92, 343.

[36] Tanferna M., Panazzolo A., Chiappa A., Fantoni A., Amosso B., Ferreri S., et al.: “Giant-cell schwannoma of the round ligament. Description of a clinical case”. Minerva Ginecol., 1986, 38, 407.

[37] Pulle C.: “Anatomoclinical considerations of a neurinoma of the urethrovaginal septum”. Arch. Ostet. Ginecol.,1959, 64, 956.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time

Conferences

Top