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Malignant mesonephric tumor of the cervix with an initial manifestation as pulmonary metastasis: case report and review of the literature

  • M.K. Yeo1
  • S.Y. Choi1
  • M. Kim1
  • K.H. Kim1
  • K.S. Suh1,*,

1 Department of Pathology, Chungnam National University School of Medicine, Daejeon, Republic of Korea

DOI: 10.12892/ejgo2810.2016 Vol.37,Issue 2,April 2016 pp.270-277

Published: 10 April 2016

*Corresponding Author(s): K.S. Suh E-mail:


Malignant mesonephric tumor (MMT) is a relatively uncommon malignancy of the female genital tract. The diagnosis of metastatic MMT is difficult because cytological, pathological, immunohistochemical characteristics of MMT are under-recognized. The authors present a 55-year-old female with metastatic pulmonary nodules. The bronchial washing cytology revealed three dimensional clusters of bland epithelial cells with slight nuclear grooves. A corresponding lung histology had ductal or tubular clusters of epithelial cells with intraglandular eosinophilic materials. These epithelial cells were positive for immunohistochemical stain of CD10, suggesting metastasis from MMT. The cervical smear showed clusters of bland, gland-forming epithelial cells with intraglandular eosinophilic materials. On histologic examination, mesonephric adenocarcinoma with papillary and solid proliferation was identified in the uterine cervix. A review of the literature for 72 cases of MMT is also included. Clinical and cytopathological features of MMT are herein made available.


Malignant mesonepehric tumor; Mesonephric adenocarcinoma; Uterus; Cytology; Pathology; Immunohistochemistry.

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M.K. Yeo,S.Y. Choi,M. Kim,K.H. Kim,K.S. Suh. Malignant mesonephric tumor of the cervix with an initial manifestation as pulmonary metastasis: case report and review of the literature. European Journal of Gynaecological Oncology. 2016. 37(2);270-277.


[1] Hinchey W.W., Silva E.G., Guarda L.A., Ordonez N.G., Wharton J.T.: “Paravaginal wolffian duct (mesonephros) adenocarcinoma: a light and electron microscopic study”. Am. J. Clin. Pathol., 1983, 80, 539.

[2] Ferry J.A., Scully R.E.: “Mesonephric remnants, hyperplasia, and neoplasia in the uterine cervix. A study of 49 cases”. Am. J. Surg. Pathol., 1990, 14, 1100.

[3] Kurman R., Carcanjiu M., Herrington S., Young R. (eds): “WHO classification of tumours of female reproductive organs”. Lyon: IARC, 2014.

[4] Wani Y., Notohara K., Tsukayama C.: “Mesonephric adenocarcinoma of the uterine corpus: a case report and review of the literature”. Int. J. Gynecol. Pathol., 2008, 27, 346.

[5] Stewart C.J., Taggart C.R., Brett F., Mutch A.F.: “Mesonephric adenocarcinoma of the uterine cervix with focal endocrine cell differentiation”. Int. J. Gynecol. Pathol., 1993, 12, 264.

[6] Lang G., Dallenbach-Hellweg G.: “The histogenetic origin of cervical mesonephric hyperplasia and mesonephric adenocarcinoma of the uterine cervix studied with immunohistochemical methods”. Int. J. Gynecol. Pathol., 1990, 9, 145.

[7] Angeles R.M., August C.Z., Weisenberg E.: “Pathologic quiz case: an incidentally detected mass of the uterine cervix. Mesonephric adenocarcinoma of the cervix”. Arch. Pathol. Lab. Med., 2004, 128, 1179.

[8] Silver S.A., Devouassoux-Shisheboran M., Mezzetti T.P., Tavassoli F. A.: “Mesonephric adenocarcinomas of the uterine cervix: a study of 11 cases with immunohistochemical findings”. Am. J. Surg. Pathol., 2001, 25, 379.

[9] Ersahin C., Huang M., Potkul R.K., Hammadeh R., Salhadar A.: “Mesonephric adenocarcinoma of the vagina with a 3-year follow-up”. Gynecol. Oncol., 2005, 99, 757.

[10] Lopez-Chardi L., Gonzalez-Bosquet E., Rovira Zurriaga C., Lailla Vicens J.M.: “Mesonephric carcinosarcoma of the uterine cervix: a case report”. Eur. J. Gynaecol. Oncol., 2013, 34, 336.

[11] Nomoto K., Hayashi S., Tsuneyama K., Hori T., Ishizawa S.: “Cytopathology of cervical mesonephric adenocarcinoma: a report of two cases”. Cytopathology, 2013, 24, 129.

[12] Buntine D.W.: “Adenocarcinoma of the uterine cervix of probable Wolffian origin”. Pathology, 1979, 11, 713.

[13] Clement P.B., Young R.H., Keh P., Ostor A.G., Scully R.E.: “Malignant mesonephric neoplasms of the uterine cervix. A report of eight cases, including four with a malignant spindle cell component”. Am. J. Surg. Pathol., 1995, 19, 1158.

[14] Bloch T., Roth L.M., Stehman F.B., Hull M.T., Schwenk G.R. Jr.: “Osteosarcoma of the uterine cervix associated with hyperplastic and atypical mesonephric rests”. Cancer, 1988, 62, 1594.

[15] Bague S., Rodriguez I.M., Prat J.: “Malignant mesonephric tumors of the female genital tract: a clinicopathologic study of 9 cases”. Am. J. Surg. Pathol., 2004, 28, 601.

[16] Meguro S., Yasuda M., Shimizu M., Kurosaki A., Fujiwara K.: “Mesonephric adenocarcinoma with a sarcomatous component, a notable subtype of cervical carcinosarcoma: a case report and review of the literature”. Diagn. Pathol., 2013, 8, 74.

[17] Montagut C., Marmol M., Rey V., Ordi J., Pahissa J., Rovirosa A., et al.: “Activity of chemotherapy with carboplatin plus paclitaxel in a recurrent mesonephric adenocarcinoma of the uterine corpus”. Gynecol. Oncol., 2003, 90, 458.

[18] Valente P.T., Susin M.: “Cervical adenocarcinoma arising in florid mesonephric hyperplasia: report of a case with immunocytochemical studies”. Gynecol. Oncol., 1987, 27, 58.

[19] Daya D., Murphy J., Simon G.: “Paravaginal female adnexal tumor of probable wolffian origin”. Am. J. Surg. Pathol., 1994, 101, 275.

[20] Arber D., Weiss L.: “CD10-A review”. Appl. Immunohistochem. Mol. Morphol., 1997, 5, 125.

[21] Ordi J., Romagosa C., Tavassoli F.A., Nogales F., Palacin A., Condom E. et al.: “CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors”. Am. J. Surg. Pathol., 2003, 27, 178.

[22] Kenny S.L., McBride H.A., Jamison J., McCluggage W.G.: “Mesonephric adenocarcinomas of the uterine cervix and corpus: HPV-negative neoplasms that are commonly PAX8, CA125, and HMGA2 positive and that may be immunoreactive with TTF1 and hepatocyte nuclear factor 1-beta”. Am. J. Surg. Pathol., 2012, 36, 799.

[23] Gupta O.P., Guirguis M.N., Diejomaoh F.: “Mesonephric adenocar-cinoma of cervix: a case report”. Int J Gynaecol Obstet., 1988, 26, 137.

[24] Yamamoto Y., Akagi A., Izumi K., Kishi Y.: “Carcinosarcoma of the uterine body of mesonephric origin”. Pathol. Int., 1995, 45, 303.

[25] Ordi J., Nogales F.F., Palacin A., Marquez M., Pahisa J., Vanrell J.A., et al.: “Mesonephric adenocarcinoma of the uterine corpus: CD10 expression as evidence of mesonephric differentiation”. Am. J. Surg. Pathol., 2001, 25, 1540.

[26] Kondi-Pafitis A., Kairi E., Kontogianni K.I., Dimopoulou C., Sikiotis K., Smyrniotis V.: “Immunopathological study of mesonephric lesions of cervix uteri and vagina”. Eur. J. Gynaecol. Oncol., 2003, 24, 154.

[27] Marquette A., Moerman P., Vergote I., Amant F.: “Second case of uterine mesonephric adenocarcinoma”. Int. J. Gynecol. Cancer, 2006, 16, 1450.

[28] Yap O.W., Hendrickson M.R., Teng N.N., Kapp D.S.: “Mesonephric adenocarcinoma of the cervix: a case report and review of the literature”. Gynecol. Oncol., 2006, 103, 1155.

[29] Bifulco G., Mandato V.D., Mignogna C., Giampaolino P., Di Spiezio Sardo A., De Cecio R., et al.: “A case of mesonephric adenocarcinoma of the vagina with a 1-year follow-up”. Int. J. Gynecol. Cancer, 2008, 18, 1127.

[30] Fukunaga M., Takahashi H., Yasuda M.: “Mesonephric adenocar-cinoma of the uterine cervix: a case report with immunohistochemical and ultrastructural studies”. Pathol. Res. Pract., 2008, 204, 671.

[31] Anagnostopoulos A., Ruthven S., Kingston R.: “Mesonephric adenocarcinoma of the uterine cervix and literature review”. BMJ Case Rep., 2012, 2012.

[32] Menon S., Kathuria K., Deodhar K., Kerkar R.: “Mesonephric adenocarcinoma (endometrioid type) of endocervix with diffuse mesonephric hyperplasia involving cervical wall and myometrium: an unusual case report”. Indian J. Pathol. Microbiol., 2013, 56, 51.

[33] Tseng C.E., Chen C.H., Chen S.J., Chi C.L.: “Tumor rupture as an initial manifestation of malignant mesonephric mixed tumor: a case report and review of the literature”. Int. J. Clin. Exp. Pathol., 2014, 7, 1212.

[34] Yao Y., Han J., Liu C.: “Mesonephric adenocarcinoma of the vaginal- urethral interspace”. Chin. Med. J., 2014, 127, 984.

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