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Brenner tumour of the ovary - an incidental histological finding

  • P. Tsikouras1,*,
  • G. Galazios1
  • K. Romanidis2
  • P. Pinidis1
  • P. Pinidis3
  • A. Giatromanolaki3
  • E. Sivridis3

1Department of Obstetrics and Gynecology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

2Second Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

3Department of Pathology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

DOI: 10.12892/ejgo2815.2016 Vol.37,Issue 2,April 2016 pp.267-269

Published: 10 April 2016

*Corresponding Author(s): P. Tsikouras E-mail:


Brenner tumours of the ovary are uncommon neoplasms and mostly benign. There is general agreement that Brenner tumors are derived from the surface epithelium of the ovary or the pelvic mesothelium through transitional cell metaplasia. It is essential to categorise these tumours as benign, borderline or malignant type as the biologic behaviour and choice of surgery differs in all of the three categories. The authors report a case of Brenner tumour that had only a single area with a beginning indistinct stroma vessel invasion. However the presence of characteristic epithelial nests, fibromatous stroma, and marked cytological metaplasia without atypia provided important clues to the correct diagnosis - proof of a benign tumour.


Ovary Brenner tumour; Benign.

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P. Tsikouras,G. Galazios,K. Romanidis,P. Pinidis,P. Pinidis,A. Giatromanolaki,E. Sivridis. Brenner tumour of the ovary - an incidental histological finding. European Journal of Gynaecological Oncology. 2016. 37(2);267-269.


[1] Alcántara Vázquez A., Chanona Ilchis J., Rivera Serrano E.P., Telles S.: “Transitional cell tumor of the ovary. Revision of a 20-year surgical material of the department of pathology at the Mexico General Hospital”. Ginecol. Obstet. Mex., 1997, 65, 339.

[2] Bernárdez F.J., Andrade Sánchez A., González Vargas J.: “Brenner tumor. Report of a case and experience at the Spanish Hospital in Mexico” Ginecol. Obstet. Mex., 1999, 67, 258.

[3] Kanajet D., Pirkić A.: “Brenner's tumor of the ovary”. Jugosl. Ginekol. Perinatol., 1990, 30, 54.

[4] Karseladze A.I.: “On the site of origin of epithelial tumors of the ovary” Eur. J. Gynaecol. Oncol., 2001, 22, 110.

[5] Kondi-Pafiti A., Kairi-Vassilatou E., Iavazzo Ch., Vouza E., Mavrigiannaki P., Kleanthis Ch., et al.: “Clinicopathological features and immunoprofile of 30 cases of Brenner ovarian tumors” Arch. Gynecol. Obstet., 2012, 285, 1699.

[6] Guerrero-Martínez E., Mateos-Vizcayno J., Huerta-Hentschel J.M.: “Brenner tumor: one case report and bibliographic review”. Ginecol. Obstet. Mex., 2014, 82, 415.

[7] Samantaray S., Rout N., Mishra D.P., Mallik R.N.: “Proliferating Brenner tumour of ovary--a case report”. Indian J. Pathol. Micro-biol., 2003, 46, 641.

[8] Singh R.I., Rosen L., Reddy V.B., Bitterman P., Stemm M.H., Gattuso P.: “Intraoperative imprint cytology of ovarian transitional cell (Brenner) tumors: a retrospective study”. Diagn. Cytopathol., 2014, 42, 660.

[9] Ziadi S., Trimeche M., Hammedi F., Hidar S., Sriha B., Mestiri S., Korbi S.: “Bilateral proliferating Brenner tumor of the ovary associated with recurrent urothelial carcinoma of the urinary bladder”. N. Am. J. Med. Sci., 2010, 2, 39.

[10] Jayalakshmy P.S., Poothiode U., Krishna G., Jayalakshmy P.L.: “Ovarian fibroma with serous cystadenoma-an unusual combination: a case report”. Case Rep. Obstet. Gynecol., 2012, 2012, 641085. doi: 10.1155/2012/641085. Epub 2012 Jul 16.

[11] Nomura K., Aizawa S.: “A histogenetic consideration of ovarian mucinous tumors based on an analysis of lesions associated with teratomas or Brenner tumors”. Pathol. Int., 1997, 47, 862.

[12] Heye S., Bielen D., Vanbeckevoort D.: “Left ovarian Brenner tumor”. JBR-BTR, 2005, 88, 245.

[13] Indraccolo U., Cingolani N., Indraccolo S.R.: “Bilateral Brenner tumor with endometrial adenocarcinoma in a postmenopausal woman”. Eur. J. Gynaecol. Oncol., 2007, 28, 233.

[14] Balasa R.W., Adcock L.L., Prem K.A., Dehner L.P.: “The Brenner tumor: a clinicopathologic review”. Obstet. Gynecol., 1977, 50, 120.

[15] Roth L.M., Dallenbach-Hellweg G., Czernobilsky B.: “Ovarian Brenner tumors. I. Metaplastic, proliferating, and of low malignant potential”. Cancer, 1985, 56, 582.

[16] Dierickx I., Valentin L., Van Holsbeke C., Jacomen G., Lissoni A.A, Licameli A., et al.: “Imaging in gynecological disease (7): clinical and ultrasound features of Brenner tumors of the ovary”. Ultrasound Obstet. Gynecol., 2012, 40, 706. doi: 10.1002/uog.11149. Epub 2012 Nov 8.

[17] Green G.E., Mortele K.J., Glickman J.N., Benson C.B.: “Brenner tumors of the ovary: sonographic and computed tomographic imaging features”. J. Ultrasound Med., 2006, 25, 1245.

[18] Hermanns B., Faridi A., Rath W., Fuzesi L., Schroder W.: “Differential diagnosis, prognostic factors, and clinical treatment of proliferative Brenner tumor of the ovary”. Ultrastruct. Pathol., 2000, 24, 191.

[19] Borah T., Mahanta R.K., Bora B.D., Saikia S.: “Brenner tumor of ovary: an incidental finding”. J. Midlife Health, 2011, 2, 40. doi: 10.4103/0976-7800.83273.

[20] Ben Aissia N., Sadfi A., Youssef A., El Ayeb A., Chadli A., Mzabi R., Gara M.F.: “Malign Brenner's tumor particularities and coverage”. Tunis Med., 2004, 82, 701.

[21] Marwah N., Mathur S.K., Marwah S., Singh S., Karwasra R.K., Arora B.: “Malignant Brenner tumour--a case report”. Indian J. Pathol. Microbiol., 2005, 48, 251.

[22] Ulbright T.M., Roth L.M.: “Common epithelial tumors of the ovary: proliferating and of low malignant potential”. Semin. Diagn. Pathol., 1985, 2, 2.

[23] Sugimura K., Okizuka H., Imaoka I.: ‘Malignant Brenner tumor: MR findings”. AJR Am. J. Roentgenol., 1991, 157, 1355.

[24] Takahama J., Ascher S.M., Hirohashi S., Takewa M., Ito T., Iwasaki S., Kichikawa K.: “Borderline Brenner tumor of the ovary: MRI findings”. Abdom. Imaging, 2004, 29, 528. Epub 2004 Mar 18.

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