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Original Research

Open Access

Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy?

  • D. Akdag Cirik1,*,
  • A. Karalok1
  • I. Ureyen1
  • T. Tasci1
  • S. Koc1
  • T. Turan1
  • G. Tulunay1

1Department of Gynecologic Oncology, Ankara Etlik Zubeyde Hanım Women's Health Training and Research Hospital, Ankara, Turkey

DOI: 10.12892/ejgo2831.2016 Vol.37,Issue 2,April 2016 pp.226-231

Published: 10 April 2016

*Corresponding Author(s): D. Akdag Cirik E-mail: deryaakdag@yahoo.com

Abstract

Purpose: To determine the impact of clinical variables and adjuvant therapy on survival in patients with Stage IVB endometrial cancer (EC) confined to abdomen. Methods and Methods: A total of 65 patients were included. Curative chemotherapy was defined as using only chemotherapy (platin based) or sandwich therapy. Patients receiving only radiotherapy had standard pelvic radiotherapy and extended-field radiotherapy when necessary. Results: The optimal cytoreduction was achieved in 89.3% of patients. With a median follow- up of 18 months, two-year progression free survival (PFS) and overall survival (OS) were calculated as 33.4% and 42.2%, respectively. Optimal cytoreduction provided more longer PFS and OS compared to suboptimal cytoreduction. In univariate analysis, curative chemotherapy instead of radiotherapy improved the two-year PFS and two-year OS. Type of adjuvant therapy, tumor grade, and peritoneal cytology were found as the independent prognostic factors for PFS. Peritoneal cytology, adnexal involvement, and adjuvant therapy were independent prognostic factor for OS. Conclusion: Curative chemotherapy significantly improved both two-year PFS and OS in patients with Stage IVB endometrial disease confined to abdomen over only radiotherapy.

Keywords

Stage IVB endometrial cancer; Adjuvant therapy; Progression free survival; Overall survival.

Cite and Share

D. Akdag Cirik,A. Karalok,I. Ureyen,T. Tasci,S. Koc,T. Turan,G. Tulunay. Stage IVB endometrial cancer confined to the abdomen: is chemotherapy superior to radiotherapy?. European Journal of Gynaecological Oncology. 2016. 37(2);226-231.

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