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Primary mediastinal choriocarcinoma with brain metastasis in a female patient

  • I. Kuno1,*,
  • Y. Matsumoto2
  • M. Kasai1
  • T. Fukuda1
  • Y. Hashiguchi1
  • T. Ichimura1
  • T. Yasui1
  • T. Sumi1

1Department of Obstetrics and Gynecology, Osaka City University, Graduate School of Medicine, Osaka, Japan

2Department of Obstetrics and Gynecology, Kishiwada City Hospital, Osaka, Japan

DOI: 10.12892/ejgo2833.2016 Vol.37,Issue 2,April 2016 pp.265-266

Published: 10 April 2016

*Corresponding Author(s): I. Kuno E-mail:


Nongestational choriocarcinoma is very rare and carries a poor prognosis in female patients. In this report, the authors present a case of nongestational choriocarcinoma with brain metastasis in a female. A 58-year-old female with intermittent back pain was referred to a private hospital. On examination, a mediastinal tumor and a pancreatic tumor were detected. Endoscopic ultrasound-guided fine needle aspiration biopsy of the tumor was performed for histological evaluation. Pathological diagnosis was difficult because only a small amount of tissue was collected. Head MRI showed multiple metastatic tumors in the brain. The patient was diagnosed with primary mediastinal choriocarcinoma with brain metastasis. She was treated with one course of an etoposide, methotrexate, dactinomycin, cyclophosphamide, and vincristine regimen, but her general condition gradually deteriorated, and she died on day 41. Nongestational choriocarcinoma is drug resistant, whereas gestational choriocarcinoma has better chemotherapeutic sensitivity.


Nongestational choriocarcinoma; Mediastinal tumor.

Cite and Share

I. Kuno,Y. Matsumoto,M. Kasai,T. Fukuda,Y. Hashiguchi,T. Ichimura,T. Yasui,T. Sumi. Primary mediastinal choriocarcinoma with brain metastasis in a female patient. European Journal of Gynaecological Oncology. 2016. 37(2);265-266.


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[2] Cheung A.N., Zhang H.J., Xue W.C., Siu M.K.: “Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives”. Future Oncol., 2009, 5, 217.

[3] International Germ Cell Cancer Collaborative Group: “International Germ cell consensus classification: a prognostic factor-based staging system for metastatic germ cell cancer”. J. Clin Oncol., 1997, 15, 594.

[4] Newlands E.S., Holden L., Seckl M.J., McNeish I., Strickland S., Rustin G.J.: “Management of brain metastases in patients with high-risk gestational trophoblastic tumors”. J. Reprod. Med., 2002, 47, 465.

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