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Twin delivery after IVF-ET with variable dose letrozole-FSH protocol of lower estradiol in a patient previously treated for breast cancer: a case report

  • Chang-Jun Zhang1
  • Ying Zhang1
  • Guang-Zhu Hu2
  • Honglu Diao1,*,

1Reproductive Medical Center, Renmin Hospital, Shiyan, Hubei, China

2Department of Thoracic and Cardiomacrovascular Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, China

DOI: 10.12892/ejgo2837.2016 Vol.37,Issue 2,April 2016 pp.278-281

Published: 10 April 2016

*Corresponding Author(s): Honglu Diao E-mail:


Objective: To present a case of twin pregnancy obtained by in vitro fertilization and embryo transfer (IVF-ET) with variable dose letrozole- FSH protocol of lower peak estradiol level, after treatment of carcinoma of the breast. Materials and Methods: A 34-year-old patient diagnosed with mucinous breast carcinoma undergoing assisted fertilization treatment after breast cancer operation and treatment including controlled ovarian stimulation (COS), oocyte retrieval, IVF, and embryo culture and transfer. Results: Four oocytes were obtained in three COS procedures in the three IVF cycle. All oocytes were fertilized. In the third cycle, two fresh embryos were transferred, and two healthy girls were born at 37 gestational weeks. Conclusion: Variable dose letrozole-FSH protocol can maintain lower peak estradiol levels and reduce estrogen exposure after breast cancer operation and chemotherapy.


Breast cancer; Variable dose letrozole-FSH protocol; IVF-ET; Twin pregnancy.

Cite and Share

Chang-Jun Zhang,Ying Zhang,Guang-Zhu Hu,Honglu Diao. Twin delivery after IVF-ET with variable dose letrozole-FSH protocol of lower estradiol in a patient previously treated for breast cancer: a case report. European Journal of Gynaecological Oncology. 2016. 37(2);278-281.


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