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Ovarian cancer diagnosed accidentally during treatment for ruptured ectopic pregnancy: is fertility-sparing surgery a viable alternative? Case report and review of the literature

  • P. Jarmużek1
  • G. Panek1
  • M. Gajewska1,*,
  • M. Wielgoś1

1Department of Obstetrics and Gynecology, Medical University of Warsaw, Warsaw, Poland

DOI: 10.12892/ejgo2841.2016 Vol.37,Issue 2,April 2016 pp.282-285

Published: 10 April 2016

*Corresponding Author(s): M. Gajewska E-mail: ma.gajewska@gmail.com

Abstract

According to cancer incidence statistics, it is estimated that 226,000 women are diagnosed annually with epithelial ovarian cancer (EOC) and 140,000 die of the disease worldwide. Ovarian cancer represents the fourth leading cause of all cancer-related deaths in women, and the first cause of death among all gynecological malignancies. With the constant shift towards later parenthood, the growing incidence of EOC in women of reproductive age is noted. Most young EOC women are concerned with preserving their fertility despite oncological outcomes. Nowadays gynecologic oncologists are being asked to include into their decision-making processes the patients' desire for fertility preserving alternatives. The question remains whether it is possible to use fertility-sparing surgery (FSS) without compromising the survival. In the present report, the authors present a case of a 27-year-old patient with ovarian cancer accidentally diagnosed during surgical treatment of an ectopic pregnancy. In this paper, the proper selection of the patients for the conservative management, oncological safety, indications for subsequent chemotherapy, the risk of relapses, obstetrical outcomes, and further oncological control were analyzed based on the largest and most relevant series outcomes data and recommendations. Numerous recent studies have confirm that FSS in young women with early stage of epithelial ovarian cancer, who wish to preserve their childbearing potential, after appropriate selection, appears a viable and safe option. However, there is still a possibility of relapse and regular oncological control is strongly recommended.

Keywords

Epithelial ovarian cancer; Fertility-sparing surgery (FSS); Obstetrical outcome; Ectopic pregnancy.

Cite and Share

P. Jarmużek,G. Panek,M. Gajewska,M. Wielgoś. Ovarian cancer diagnosed accidentally during treatment for ruptured ectopic pregnancy: is fertility-sparing surgery a viable alternative? Case report and review of the literature. European Journal of Gynaecological Oncology. 2016. 37(2);282-285.

References

[1] DiSaia P.J.: “Fertility- sparing treatment of patient with ovarian cancer”. Compr. Ther., 1990, 16, 35.

[2] Park J.Y., Kim D.Y., Suh D.S., Kim J.H., Kim Y.M., Kim Y.T., Nam J. H.: “Outcomes of fertility sparing surgery for invasive epithelial ovarian cancer: oncologic safety and reproductive outcomes”. Gynecol. Oncol., 2008, 110, 345.

[3] Schilder J.M., Thompson A.M., DePriest P.D., Ueland F.R., Cibull M.L., Kryscio R.J., et al.: “Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancertreated with fertilitysparing therapy”. Gynecol. Oncol., 2002, 87, 1.

[4] Anchezar J.P., Sardi J., Soderini A.: “Long-term follow up results of fertility sparing surgery in patients with ephitelial ovarian cancer”. J. Surg. Oncol., 2009, 100, 55.

[5] Markowska J., Mądry R., Markowska A. (eds).: “Ginekologia onkologiczna”. Chapter 11.16.6. Wrocław: Med. Pharm Polska, 2008, 175.

[6] Zapardiel I., Diestro M.D., Aletti G.: “Conservative treatment of early stage ovarian cancer: oncological and fertility outcomes”. Eur. J. Surg. Oncol., 2014, 40, 387.

[7] Fruscio R., Corso S., Ceppi L., Garavaglia D., Garbi A., Floriani I., et al.: “Conservative management of early stage epithelial ovarian cancer: results of a large retrospective series”. Ann. Oncol., 2013, 24, 138.

[8] Schilder J.M., Thompson A.M., DePriest P.D., Ueland F.R., Cibull M.L., Kryscio R.J., et al.: “Outcome of reproductive age women with stage IA or IC invasive epithelial ovarian cancer treated with fertility sparing therapy”. Gynecol. Oncol., 2002, 87, 1.

[9] Satoh T., Hatae M., Watanabe Y., Yaegashi N., Ishiko O., Kodama S., et al.: “Outcomes of fertility- sparing surgery for stage I epithelial ovarian cancer: a proposal for patient selection”. J. Clin. Oncol., 2010, 28, 1727.

[10] Morice P., Leblanc E., Rey A., Baron M., Querleu D., Blanchot J., et al.: “GCCLCC and SFOG. Conservative treatment in epithelial ovarian cancer: results of a multicentre study of the GCCLCC (Groupe des Chirurgiens de Centre de Lutte Contre le Cancer) and SFOG (Société Francaise d'Oncologie Gynécologique)”. Hum. Reprod., 2005, 20, 1379.

[11] Vergote I., De Brabanter J., Fyles A., Bertelsen K., Einhorn N., Sevelda P., et al.: “Prognostic importance of degree of differentiation and cyst rupture in stage I invasive epithelial ovarian carcinoma”. Lancet, 2001, 357, 176.

[12] Tingulstad S., Skjeldestad F.E., Halvorsen T.B., Hagen B.: “Survival and prognostic factors in patient with ovarian cancer”. Obstet. Gynecol., 2003, 101, 885.

[13] Tang I., Zheng M., Xiong Y., Ding H., Lui F.Y.: “Clinical characteristics and prognosis of epithelial ovarian cancer in young woman”. Ai Zheng, 2008, 27, 951.

[14] Fotopoulou C., Braicu I., Sehouli J.: “Fertitity sparing in early epithelial ovarian cancer: a viabile option?” Obstet. Gynecol. Int., 2012, 2012, 238061.

[15] Heintz A.P., Odicino F., Maisonneuve P., Quinn M.A., Benedet J.L., Creasman W.T., et al.: “Carcinoma of the ovary. FIGO 26th Annual Report on the result of treatment in gynecological cancer”. Int. J. Gynaecol. Obstet., 2006, 95, S161.

[16] Pectasides D., Fountzilas G., Aravantinos G., Bamias A., Kalofonos

H. P., Skarlos D., et al.: “Epithelial ovarian carcinoma in younger vs older women: is age an independent prognostic factor? The Hellenic Oncology Cooperative group experience”. Int. J. Gynecol. Cancer, 2007, 17, 1003.

[17] Colombo N., Peiretti M., Parma G., Lapresa M., Mancari R., Carinelli S., et al.: “Newly diagnosed end relapsed epithelial ovarian carcinoma. ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up”. Ann. Oncol., 2010, 21, 23.

[18] JemalA., Bray F., Center M.M., Ferlay J., Ward E., Forman D.: “Global cancer statistics”. CA Cancer J. Clin., 2011, 61, 69.

[19] Tewari K.S., DiSaia P.J.: “Ovulatory failure, fertility preservation and reproductive strategies in the setting of gynecologic and non- gynecologicla malignancies”. Eur. J. Gynaecol. Oncol., 2006, 27, 449.

[20] Kuś E., Świerczewski A., Estemberg D., Kowalska-Koprek U., Brzozowska M., Berner-Trąbska M., et al.: “Course of pregnancy and delivery in a patient with ovarian cancer after conservative surgical treatment – case report”. Ginekol. Pol., 2010, 81, 65.

[21] American College of Obstetrics and Gynecologists: “ACOG practice bulletin. Management of adnexal masses”. Obstet. Gynecol., 2007, 110, 201.

[22] Aebi S., Castiglione M., ESMO Guidelines Working Group.: “Epithelial ovarian carcinoma: ESMO clinical recommendations for diagnosis, treatment and follow-up”. Ann. Oncol., 2008, 19, :ii14-6. doi: 10.1093/annonc/mdn073.

[23] Morice P., Denschlag D., Rodolakis A., Reed N., Schneider A., Kesic V., Colombo N., et al.: “Recommendations of the Fertility Task Force of the European Society of Gynecologic Oncology about the conservative management of ovarian malignant tumors”. Int. J. Gynecol. Cancer, 2011, 21, 951.

[24] Salani R., Bristow R.E.: “Surgical management of epithelial ovarian cancer”. Clin. Obstet. Gynecol., 2012, 55, 75.

[25] Kajiyama H., Mizuno M., Shibata K., Yamamoto E., Kawai M., Nagasaka T., Kikkawa F.: “Recurrence-predicting prognostic factors for patients with early-stage epithelial ovarian cancer undergoing fertility-sparing surgery: a multi-institutional study”. Eur. J. Obstet. Gynecol. Reprod. Biol., 2014, 175, 97.

[26] du Bois A., Heitz F., Harter P.: “Fertility-sparing surgery in ovarian cancer: a systematic review”. Onkologie, 2013, 36, 436.

[27] Borgfeldt C., Iosif C., Måsbäck A.: “Fertility-sparing surgery and outcome in fertile women with ovarian borderline tumors and epithelial invasive ovarian cancer”. Eur. J. Obstet. Gynecol.. Reprod. Biol., 2007, 134, 110.

[28] Shiota M., Kotani Y., Umemoto M., TobiumeT., Hoshiai H.: “Study of the correlation between tumor size and cyst rupture in laparotomy and laparoscopy for benign ovarian tumor”. J. Obstet. Gynaecol. Res., 2012, 38, 531.

[29] Huber D., Cimorelli V., Usel M., Bouchardy C., Rapiti E., Patignat P.” “How many ovarian cancer patients are eligible for fertility- sparing surgery?” Eur. J. Obstet. Gynecol.. Reprod. Biol., 2013, 170, 270.

[30] Szymański M., Socha M., Szymański W.: “Fertility sparing surgery (FSS) in patients with epithelial ovarian cancer”. Ginekol. Prakt., 2005, 82, 2.


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