Pure non-gestational choriocarcinoma arising in the ovary

Non-gestational choriocarcinoma (NGCO) is a rare primary ovarian cancer with poor prognosis. It is important to distinguish it from gestational ovarian choriocarcinoma (GCO), because there are different treatment options. However, it is difficult to distinguish the two types by routine histologic, ultrastructural, or immunohistochemical examination. The authors present NGCO in a 41-yearold woman, which was confirmed by DNA polymorphism analysis. All tested microsatellite markers had identical DNA profiles with the same allelic sizes between tumor and normal myometrium of the patient, indicating that both tissues originated from the same person. The results confirmed that the tumor was non-gestational in origin. Although the tumor was large, the authors performed handassisted laparoscopic surgical (HALS) staging. After three cycles of combination chemotherapy and surgery, the patient has not had any evidence of disease 48 months after treatment. This case demonstrates the usefulness of HALS staging and DNA polymorphism analysis in NGCO.

DNA polymorphism analysis; Hand-assisted laparoscopy; Non-gestational choriocarcinoma; Ovary.

[1] Chen V.W., Ruiz B., Killeen J.L., Cote T.R., Wu X.C., Correa C.N.: “Pathology and classification of ovarian tumors”. Cancer, 2003, 97, 2631.

[2] Kong B., Tian Y.J., Zhu W.W., Qin Y.J.: “A pure nongestational ovarian choriocarcinoma in a 10-year-old girl: case report and literature review”. J. Obstet. Gynaecol. Res., 2009, 35, 574.

[3] Koo H.L., Choi J., Kim K.R., Kim J.H.: “Pure non-gestational choriocarcinoma of the ovary diagnosed by DNA polymorphism analysis”. Pathol. Int. 2006, 56, 613.

[4] Oladipo A., Mathew J., Oriolowo A.,Lindsay I., Fisher R., Seclkl M., et al.: “Nongestational choriocarcinoma arising from a primary ovarian tumour”. BJOG, 2007, 114, 1298.

[5] Goswami D., Sharma K., Zutshi V., Tempe A., Nigam S.: “Nongestational pure ovarian choriocarcinoma with contralateral teratoma”. Gynecol. Oncol., 2001, 80, 262.

[6] Ghezzi F., Cromi A., Uccella S., Bermini V., Tomera S., Franchi M., et al.: “Laparoscopy versus laparotomy for the surgical management of apparent early stage ovarian cancer”. Gynecol. Oncol., 2007, 105, 409.

[7] Smith H.O., Berwick M., Verschraegen C.F., Winggins C., Lansing L, Muller C.Y., et al.: “Incidence and survival rates for female malignant germ cell tumors”. Obstet. Gynecol., 2006, 107, 1075. [8] Park S.H., Park A., Kim J.Y., Kwon J.H., Koh S.B.: “A case of nongestational choriocarcinoma arising in the ovary of a postmenopausal woman”. J. Gynecol. Oncol., 2009, 20, 192.

[9] Jiao L.Z., Xiang Y., Feng F.Z., Wan X.R., Zhao J., Cui Q.C., et al.: “Clinical analysis of 21 cases of nongestational ovarian choriocarcinoma”. Int. J. Gynecol. Cancer, 2010, 20, 299.

[10] Tsujioka H., Hamada H., Miyakawa T., Hachisuga T., Kawarabayashi T.: “A pure nongestational choriocarcinoma of the ovary diagnosed with DNA polymorphism analysis”. Gynecol. Oncol., 2003, 89, 540.

[11] Yamamoto E., Ino K., Yamamoto T., Sumigama S., Nawa A., Nomura S., et al.: “A pure nongestational choriocarcinoma of the ovary diagnosed with short tandem repeat analysis: case report and review of the literature”. Int. J. Gynecol. Cancer, 2007, 17, 254.

[12] Shim S.H., Kim D.Y., Lee S.W., Park J.Y., Kim J.H., Kim Y.M., et al.: “Laparoscopic management of early-stage malignant nonepithelial ovarian tumors: surgical and survival outcomes”. Int. J. Gynecol. Cancer, 2013, 23, 249.