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Presentation of a patient with in situ amelanotic melanoma of the vulva

  • P. Tsikouras1,*,
  • G. Galazios1
  • N. Tsagias1
  • A. Koukoulomati1
  • K. Romanidis2
  • A. Giatromanolaki3
  • E. Sivridis3

1Department of Obstetrics and Gynecology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

2Second Department of Surgery, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

3Department of Pathology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece

DOI: 10.12892/ejgo3135.2016 Vol.37,Issue 4,August 2016 pp.578-580

Published: 10 August 2016

*Corresponding Author(s): P. Tsikouras E-mail: ptsikour@med.duth.gr

Abstract

Amelanotic malignant melanoma of the vulva is extremely rare. The authors describe here a case of amelanotic malignant melanoma of the vulva, occurring in a 71-year-old woman without any clinical symptoms. The woman had a small nodular lesion in the left labia majora. Local excision was performed. Histological examination revealed an in situ malignant melanoma without any evidence of invasive disease. All suspicious lesions in the vulva region, even if there are no clinical symptoms, should be biopsied, and if an in-situ melanoma is identified, partial or total vulvectomy should be considered.


Keywords

Amelanotic melanoma in situ; Vulva; Treatment.

Cite and Share

P. Tsikouras,G. Galazios,N. Tsagias,A. Koukoulomati,K. Romanidis,A. Giatromanolaki,E. Sivridis. Presentation of a patient with in situ amelanotic melanoma of the vulva. European Journal of Gynaecological Oncology. 2016. 37(4);578-580.

References

[1] Lonsdale-Eccles A.A., Morgan J.M., Nagarajan S., Cruickshank D.J.: “Successful treatment of vulval melanoma in situ with topical 5% imiquimod cream”. Br. J. Dermatol., 2006, 155, 215.

[2] Ragnarsson-Olding B., Johansson H., Rutqvist L.E., Ringborg U.: “Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long term survival among 245 consecutive cases in Sweden 1960–1984”. Cancer, 1993, 71, 1983.

[3] Irvin W.P. Jr., Legallo R.L., Stoler M.H., Rice L.W., Taylor P.T., Andersen W.A.: “Vulvar melanoma: a retrospective analysis and literature review”. Gynecol. Oncol., 2001, 83, 457.

[4] Brand E., Fu Y.S., Lagasse L.D., Berek J.S.: “Vulvovaginal melanoma: report of seven cases and literature review”. Gynecol.Oncol., 1989, 33, 54.

[5] Ragnarsson-Olding B.K., Kanter-Lewensohn L.R., Lagerlöf B.,Nilsson B.R., Ringborg U.K.: “Malignant melanoma of the vulva in a nationwide 25-year study of 219 Swedish females. Clinical observations and histopathologic features”. Cancer, 1999, 86, 1273.

[6] Raber G., Mempel V., Jackisch C., Hundeiker M., Heinecke A., Kurzl R., et al.: “Malignant melanoma of the vulva. Report of 89 patients”. Cancer, 1996, 78, 2353.

[7] Wechter M.E., Gruber S.B., Haefner H.K., Lowe L., Schwartz J.L., Reynolds K.R., et al.: “Vulvar melanoma: a report of 20 cases and review of the literature”. J. Am. Acad. Dermatol., 2004, 50, 554.

[8] Phillips G.L., Bundy B.N., Okagaki T., Kucera P.R., Stehman F.B.: “Malignant melanoma of the vulva treated by radical hemivulvectomy. A prospective study of the Gynecologic Oncology Group”. Cancer, 1994, 73, 2626.

[9] Oguri H., Izumia C., Maeda N., Fukaua T., Moriki T.: “A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma”. J. Clin. Pathol., 2004, 57, 986.

[10] An J.,Li B.,Wu L., Lu H., Li N.: “Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature”. Melanoma Res., 2009, 19, 267.

[11] Patrick R.J., Fenske N.A., Messina J.L.: “Primarymucosal melanoma”. J. Am. Acad. Dermatol., 2007, 56, 828.

[12] Wain E.M., Stefanato C.M., Barlow R.J.: “A clinicopathological surprise: amelanotic malignant melanoma”. Clin. Exp. Dermatol., 2008, 33, 365.

[13] Holder J.E., Colloby P.S., Fletcher A., Camp R.D.: “Amelanotic superficial spreading malignant melanoma mimicking Bowen's disease”. Br. J. Dermatol., 1996, 134, 519.

[14] Oiso N., Yoshida M., Kawara S., Kawada A.: “Amelanotic vulvar melanoma with intratumor histological heterogeneity”. J. Dermatol., 2010, 37, 537.

[15] Khaled A., Hammami H., Fazaa B., Kourda N., Kamoun M.R., Ben Jilany S., Zoghlami A.: “Primary amelanotic anorectal melanoma: an uncommon neoplasia with poor prognosis”. Pathologica, 2009, 101, 126.

[16] Baderca F., Cojocaru S., Lazar E., Lazureanu C., Lighezan R., Alexa A.: “Amelanotic vulvar melanoma: case report and review of the literature”. Rom. J. Morphol. Embryol., 2008, 49, 219.

[17] Trimble E.L.: “Melanomas of the vulva and vagina”. Oncology (Williston Park), 1996, 10, 1017.

[18] Shetty K.J., Prasad H.L., Rai S.: “Primary amelanotic melanoma of vulva in a young, lactating female”. Indian J. Surg. Oncol., 2012, 3, 36

[19] Ulmer A., Dietl J., Schaumburg-Lever G., Fierlbeck G.: “Amelanotic melanoma of the vulva simulating lichen sclerosus et atrophicus”. Hautarzt., 1996, 47, 854.

[20] Hofmann U., Megahed M.: “Amelanotic nodular malignant melanoma of the vulva. Case report and review of the literature”. Hautarzt., 1995, 46, 850.

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