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Vulvar melanoma presenting as postmenopausal bleeding: a case report

  • A. Koumousidis1
  • C. Sofoudis1,*,
  • N. Marikakis2
  • A. Ciopec1
  • M. Adamczyk1
  • G. Vakis3
  • P. Sinha1

1Department of Obstetrics & Gynecology, Conquest Hospital, East Sussex, England

2Department of General Surgery, Conquest Hospital, East Sussex, England

3Plastic Surgery Department, National and Kapodistrian University of Athens, Athens, Greece

DOI: 10.12892/ejgo3196.2016 Vol.37,Issue 4,August 2016 pp.546-548

Published: 10 August 2016

*Corresponding Author(s): C. Sofoudis E-mail: chrisostomos.sofoudis@gmail.com

Abstract

Primary melanomas of the vulva are extremely rare, creating obstacles in the differential diagnosis of other epithelial and non-epithelial malignancies. Due to their rarity, there are only approximately 250 cases reported in the current literature. Vulvar melanomas tend to relapse locally, as well as develop locoregional and distant metastasis through lymph node and haematic dissemination. The authors describe a case of an 84-year-old Caucasian female patient, presenting with postmenopausal bleeding, consistent with primary vulvar melanoma cause, which was successfully diagnosed and treated accordingly.


Keywords

Vulvar melanoma; Chemotherapy; Radiotherapy.

Cite and Share

A. Koumousidis,C. Sofoudis,N. Marikakis,A. Ciopec,M. Adamczyk,G. Vakis,P. Sinha. Vulvar melanoma presenting as postmenopausal bleeding: a case report. European Journal of Gynaecological Oncology. 2016. 37(4);546-548.

References

[1] Platz C.E., Benda J.A.: “Female genital cancer”. Cancer, 1995, 75, 270.

[2] Chung A.F.,Woodruff J.M., Lewis J.L. Jr.: “Malignant melanoma of the vulva:A report of 44 cases”. Obstet. Gynecol.,1975, 45, 638.

[3] Räber G., Mempel V., Jackisch C., Hundeiker M., Heinecke A., Kürzl R., et al.: “Malignant melanomaof the vulva.Report of 89 patients”. Cancer, 1996, 78, 1258.

[4] Ariel I.M.: “Malignant melanoma of the female genital system: a report of 48 patients and review of the literature”. J. Surg. Oncol., 1981, 16, 371.

[5] Bradgate M.G., Rollason T.P., McConkey C.C., Powell J.: “Malignant melanoma of the vulva: a clinicopathological study of 50 women”. Br. J. Obstet. Gyneacol., 1990, 97, 124.

[6] Jaramillo B.A., Ganjei P., Averette H.E., Sevin B.U., Lovecchio J.L.:“Malignant melanoma of the vulva”. Obstet. Gynaecol., 1985, 66, 398.

[7] Sugiyama V.E., Chan J.K., Shin J.Y., Berek J.S., Osann K., Kapp D.S.: “Vulvar melanoma: a multivariable analysis of 644 patients”. Obstet. Gynecol., 2007, 110, 296.

[8] Verschraegen C.F., Benjapibal M., Supakarapongkul W., Levy L.B., Ross M., Atkinson E.N., et al.: “Vulvar melanoma at the M.D.Anderson Cancer Center: 25 years later”. Int. Gynecol. Cancer, 2001, 11, 359.

[9] Kirkwood J.M., Ibrahim J.G., Sondak V.K., Richards J., Flaherty L.E., Ernstoff M.S., et al.: “High-and low-dose interferon alfa-2b in high-risk melanoma: first analysis of intergroup trial E1690/S9111/C9190”. J. Clin. Oncol., 2000, 18, 2444.

[10] Smyth E.C., Flavin M., Pulitzer M.P., Gardner G.J., Costantino P.D., Chi D.S., et al.: “Treatment of locally recurrent mucosal melanoma with topical imiquimod”. J. Clin. Oncol., 2011, 29, e809

[11] Coit D.G., Andtbacka R., Bichakjian C.K., Dilawari R.A., Dimaio D., Guild V., et al.: “Melanoma”. J. Natl. Compr. Canc. Netw., 2009, 7, 250.

[12] Topalian S.L., Hodi F.S , Brahmer J.R., Gettinger S.N., Smith D.C., McDermott D.F., et al.: “Safety, activity and immune correlates of anti-PD-1 antibody in cancer”. N. Engl. J. Med., 2012, 366, 2443.

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