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Case Reports

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Gynandroblastoma of postmenopausal women: a case report

  • S. Shichido1,*,
  • L. Tashima1
  • K. Hori1
  • H. Kimura2
  • S.I. Nakatsuka3
  • Y. Hoshida4

1Department of Obstetrics and Gynecology, Kansai Rosai Hospital, Amagasaki-shi, Hyogo-ken, Japan

2Department of Clinical Pathology, Itami City Hospital, Itami-shi, Hyogo-ken, Japan

3Department of Pathology, Kansai Rosai Hospital, Amagasaki-shi, Hyogo-ken, Japan

4Department of Clinical Pathology, National Hospital Organization Osaka Minami Medical Center, Kawachi-Nagano-shi, Osaka, Japan

DOI: 10.12892/ejgo3201.2016 Vol.37,Issue 4,August 2016 pp.581-583

Published: 10 August 2016

*Corresponding Author(s): S. Shichido E-mail: shizuka-86@poem.ocn.ne.jp

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Abstract

Gynandroblastoma, an extremely rare ovarian tumour that usually consists of both Sertoli stromal cell and granulosa cell tumours, often produces both androgenic and estrogenic effects. The authors herein report a case of gynandroblastoma with the longest diseasefree period reported to date. A 66-year-old woman without metrorrhagia or hirsutism presented with abdominal pain and slightly elevated serum estradiol levels. Her uterus was enlarged, and endometrial curettage performed to reduce endometrial thickness prior to laparotomy led to a diagnosis of atypical endometrial hyperplasia. She was diagnosed of ovarian tumour. The pathology report revealed that the right ovarian tumour was a "gynandroblastoma". Such lesions are classified as borderline malignant. Postoperative adjuvant therapy was not administered in this case because only a few recurrent or fatal cases have been reported. The lesion was classified as pT1aN0M0 according to Union for International Cancer Control (UICC). The patient is alive and has been disease-free for 77 months post-surgery.

Keywords

Gynandroblastoma; Sex cord; Stromal cell tumours; Granulosa cell tumor; Sertoli cell tumour.

Cite and Share

S. Shichido,L. Tashima,K. Hori,H. Kimura,S.I. Nakatsuka,Y. Hoshida. Gynandroblastoma of postmenopausal women: a case report. European Journal of Gynaecological Oncology. 2016. 37(4);581-583.

URL:

https://www.ejgo.net/articles/10.12892/ejgo3201.2016

References

[1] Xiao S., Xue M., Wan Y., Su Z.: “Gynandroblastoma with the symptoms of infertility and secondary amenorrhea: a case report”. Clin. Exp. Obstet. Gynecol., 2011, 38, 419.

[2] Chivukula M., Hunt J., Carter G., Kelly J., Patel M., Kanbour-Shakir A.: “Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis”. Int. J. Gynecol. Pathol., 2007, 26, 30

[3] Lejeune J., Gallon F., Quirin I., Grignon Y.: “Gynandroblastoma andFragile X syndrome. Case report”. Gynecol. Obstet. Fe rtil., 2011, 39, e68.

[4] Limaiem F., Lahmar A., Ben Fadhel C., Bouraoui S., M’zabi Regaya S.: “Gynandroblastoma. Report of an unusual ovarian tumour and literature review”. Pathologica, 2008, 100, 13.

[5] Fox H., Langley FA.: Postgraduate obstetrical and gynecological pathology. Oxford: Pergamon Press, 1973, 225.

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