Abdominal wall mixed malignant germ cell tumor: a case report and review of literature

Abdominal wall mass is not uncommon in clinic, but it is very rare that germ cell tumors (GCTs) arise in the abdominal wall. The authors review the case of a 34-year-old female with abdominal wall mixed malignant GCT composed of embryonal carcinoma and teratoma and combine the relative literature to explain why GCTs originate from anterior abdominal wall.

Germ cell tumors; Extragonadal; Abdominal wall.

[1] Stang A., Trabert B., Wentzensen N., Cook M.B., Rusner C., Oosterhuis J.W., MoGlynn K.A.: “Gonadal and extragonadal germ cell tumours in the United States, 1973-2007”. Int. J. Androl., 2012, 35, 616.

[2] Miller K.D., Michael H., Jacobson L., Sutton G.P.: “Primary yolk sac tumor of the rectum”. Cancer Invest., 2000, 18, 597.

[3] Dehner L.P., Mills A., Talerman A., Billman G.F., Krous H.F., Platz C.E.: “Germ cell neoplasms of head and neck soft tissues: a pathologic spectrum of teratomatous and endodermal sinus tumors”. Hum. Pathol., 1990, 21, 309.

[4] Heffner D.K., Hyams V.J.: “Teratocarcinosarcoma (malignant teratoma?) of the nasal cavity and paranasal sinuses. A clinicopathologic study of 20 cases”. Cancer, 1984, 53, 2140.

[5] Rao K., Dutta T.K., Gupta A.N., Aikat M.: “Extragonadal abdominal wall malignant teratoma--a case report”. Indian J. Cancer, 1980, 17, 185.

[6] Jacob R., Ramadas K., Jyothirmayi R., Kusumakumary P., Nair M.K.: “Extragonadal germ-cell tumors: a ten-year experience”. Am. J. Clin. Oncol., 1998, 21 ,198.

[7] Bokemeyer C., Nichols C.R., Droz J.P., Schmoll H.J., Horwich A., Gerl A., et al.: “Extragonadal germ cell tumors of the mediastinum and retroperitoneum: results from an international analysis”. J. Clin. Oncol., 2002, 20, 1864.

[8] Rusner C., Trabert B., Katalinic A., Kieschke J., Emrich K., Stang A.: “Incidence patterns and trends of malignant gonadal and extragonadal germ cell tumors in Germany, 1998-2008”. Cancer Epidemiol., 2013, 37, 370.

[9] Friedman N.B.: “The function of the primordial germ cell in extragonadaltissues”. Int. J. Androl., 1987, 10, 43.

[10] Legato M.J.: “Principles of gender-specific medicine”. In: Legato M.J.(ed). Difference in germ cell tumors of the reproductive tract in men and women. 2nded. New York: Academic Press, 2009, 12.

[11] Hattab E.M., Tu P.H., Wilson J.D., Cheng L.: “OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma”. Am. J. Surg. Pathol., 2005, 29, 368.

[12] Stoop H., Honecker F., van de Geijn G.J., Gillis A.J., Cools M.C., de Boer M., et al.: “Stem cell factor as a novel diagnostic marker for early malignant germ cells”. J. Pathol., 2008, 216, 43.

[13] Liu A., Cheng L., Du J., Peng Y., Allan R.W., Wei L., et al.: “Diagnostic utility of novel stem cell markers SALL4, OCT4, NANOG, SOX2, UTF1, and TCL1 in primary mediastinal germ cell tumors”. Am. J. Surg. Pathol., 2010, 34, 697.

[14] Mueller T., Mueller L.P., Holzhausen H.J., Witthuhn R., Albers P., Schmoll H.J.: “Histological evidence for the existence of germ cell tumor cells showing embryonal carcinoma morphology but lacking OCT4 expression and cisplatin sensitivity”. Histochem. Cell. Biol.,2010, 134, 197.

[15] Sakurada K., Saino M., Mouri W., Sato A., Kitanaka C., Kayama T.: “Nestin expression in central nervous system germ cell tumors”. Neurosurg. Rev., 2008, 31, 173.

[16] Gao Y., Jiang J., Liu Q.: “Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience”. Int. J. Clin. Exp. Pathol., 2014, 7, 6965.

[17] Deutsch Y.E., Tadmor T., Podack E.R., Rosenblatt J.D.: “CD30: an important new target in hematologic malignancies”. Leuk. Lymphoma, 2011, 52, 1641.

[18] Albany C., Einhorn L.H.: “Extragonadal germ cell tumors: clinical presentation and management”. Curr. Opin. Oncol., 2013, 25, 261.

[19] Fukui N., Kohno Y., Ishioka J., Fukuda H., Kageyama Y., Higashi Y.: “Treatment outcome of patients with extragonadal nonseminomatous germ cell tumors: the Saitama Cancer Center experience”. Int. J. Clin. Oncol.,2013, 18, 731.

[20] Rodney A.J., Tannir N.M., Siefker-Radtke A.O., Liu P., Walsh G.L., Milliken R.E., et al.: “Survival outcomes for men with mediastinal germ-cell tumors: the University of Texas M. D. Anderson Cancer Center experience”. Urol. Oncol., 2012, 30, 879.