Expressions of H2AX in cervical squamous carcinoma and their clinical significances

Objective: To evaluate the expression and clinical significance of H2AX in cervical squamous carcinoma. Materials and Methods. The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data. Results: The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlated with FIGO staging, vaginal invasion, and parametrial infiltration (p < 0.05). Survival analysis showed the expression intensity of H2AX had no significant effect on the prognosis. Conclusion: H2AX was an anticancer protein for cervical squamous carcinoma.

Cervical squamous carcinoma; H2AX; Phosphorylate; Immunohistochemistry.

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