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Original Research

Open Access

A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing’s syndrome

  • Y. Chen1
  • Y. Zhang2,*,
  • L. Wang1
  • X. Yang3

1Department of Obstetrics, Central Hospital of Benxi City, Liaoning, China

2Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China

3Department of Orthopedics, Central Hospital of Beixi City, Liaoning, China

DOI: 10.12892/ejgo3348.2017 Vol.38,Issue 1,February 2017 pp.126-128

Published: 10 February 2017

*Corresponding Author(s): Y. Zhang E-mail: syzi@163.com

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Abstract

Background: To date, cervical carcinoma complicated with Cushing's syndrome were all diagnosed as small cell carcinoma histologically, but not adenosquamous carcinoma. Here the authors present the diagnosis, management, and prognosis of a case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. Case: A 28-year-old woman was admitted with the chief complaint of post-coital bleeding for one month. Gynecological examination revealed a nodular yellowish-pigmented vegetation (6×5 cm) on the cervix. Laboratory findings proved the diagnosis of Cushing’s syndrome. Histopathological diagnosis showed the adenosquamous carcinoma with melanoma differentiation. Immunohistochemical stainings for melanoma A and anti-adrenocorticotropic hormone (ACTH) were positive in the majority of the tumor cells, which indicated that this melanocytic cervical carcinoma lesion was the source of ectopic ACTH production resulting in Cushing's syndrome. Conclusion: This is a unique case of a rare type of cervical carcinoma.

Keywords

Melanocytic carcinoma; Cervical adenosquamous carcinoma; Cushing’s syndrome.

Cite and Share

Y. Chen, Y. Zhang, L. Wang, X. Yang. A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing’s syndrome. European Journal of Gynaecological Oncology. 2017; 38(1): 126-128. doi: 10.12892/ejgo3348.2017

URL:

https://www.ejgo.net/articles/10.12892/ejgo3348.2017

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