A case of melanocytic cervical adenosquamous carcinoma complicated with Cushing’s syndrome

Background: To date, cervical carcinoma complicated with Cushing's syndrome were all diagnosed as small cell carcinoma histologically, but not adenosquamous carcinoma. Here the authors present the diagnosis, management, and prognosis of a case of melanocytic cervical adenosquamous carcinoma complicated with Cushing's syndrome. Case: A 28-year-old woman was admitted with the chief complaint of post-coital bleeding for one month. Gynecological examination revealed a nodular yellowish-pigmented vegetation (6×5 cm) on the cervix. Laboratory findings proved the diagnosis of Cushing’s syndrome. Histopathological diagnosis showed the adenosquamous carcinoma with melanoma differentiation. Immunohistochemical stainings for melanoma A and anti-adrenocorticotropic hormone (ACTH) were positive in the majority of the tumor cells, which indicated that this melanocytic cervical carcinoma lesion was the source of ectopic ACTH production resulting in Cushing's syndrome. Conclusion: This is a unique case of a rare type of cervical carcinoma.

Melanocytic carcinoma; Cervical adenosquamous carcinoma; Cushing’s syndrome.

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