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Original Research

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Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases

  • M. Varras1,*,
  • E. Skafida2
  • T. Vasilakaki2
  • A. Anastasiadis1
  • C. Akrivis3
  • N. Vrachnis4
  • G. Nikolopoulos5

1Third Department of Obstetrics and Gynecology, “Elena Venizelou” General Maternity State Hospital, Athens

2Department of Pathology, “Tzaneio” General State Hospital, Piraeus

3Department of Obstetrics and Gynecology, “G. Chatzikosta” General State Hospital, Ioannina

4Second Department of Obstetrics and Gynecology, University of Athens, Athens

5,Hellenic Centre for Diseases Control and Prevention (Greece).

DOI: 10.12892/ejgo340104 Vol.34,Issue 1,January 2013 pp.31-35

Published: 10 January 2013

*Corresponding Author(s): M. Varras E-mail:


Introduction: Decreased expression of E-cadherin has been associated with poorly differentiated endometrial carcinomas and poorer outcomes. Aim: The purpose of this study was to examine the distribution of E-cadherin immunohistochemical expression in specimens from primary endometrial carcinomas and its relation to classical clinicopathological prognostic factors. Materials and Methods: Surgically-resected tissues of 30 patients with primary endometrial carcinomas were studied. Histological type and grade, depth of myometrial invasion, lymph-vascular space invasion, fallopian tube or ovarian invasion, and the presence of tumoral necrosis were evaluated. Immunohistochemical examination was performed on deparaffinized four-µm-thick sections. Results: The mean age of patients was 65 years (± 11.41). The 63.54% of carcinomas were moderately/poorly differentiated. No statistical correlation was found between the score or intensity of E-cadherin immunohistochemical staining (strong or moderate positive expression) and the clinicopathological factors tested. Conclusions: The association of E-cadherin immunoreactivity with the standard clinicopathological factors seemed to be contradictory. The classical clinicopathological factors remain the most important prognostic parameters.


E-cadherin; Carcinoma; Endometrial; Endometrioid; Immunohistochemistry; Pathology.

Cite and Share

M. Varras,E. Skafida,T. Vasilakaki,A. Anastasiadis,C. Akrivis,N. Vrachnis,G. Nikolopoulos. Expression of E-cadherin in primary endometrial carcinomas: clinicopathological and immunohistochemical analysis of 30 cases. European Journal of Gynaecological Oncology. 2013. 34(1);31-35.


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