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Original Research
Open AccessEvaluation of osteopontin and CA125 in detection
of epithelial ovarian carcinoma
Evaluation of osteopontin and CA125 in detection of epithelial ovarian carcinoma
1Center of Medical Biochemistry, Clinical Center of Serbia, Belgrade
2School of Medicine, University of Belgrade, Clinic of Gynecology and Obstetrics, Clinical Center of Belgrade, Belgrade
3Clinic of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade
4Faculty of Pharmacy, Department of Analytical Chemistry, University of Belgrade (Serbia).
*Corresponding Author(s): M. Milivojevic E-mail: mirjanamilivojevic1@gmail.com
Abstract
The objective of this study was to determine the potential of osteopontin (OPN) and OPN + CA125 (cancer antigen 125) combination in differential diagnosis of the ovarian cancers and non-malignant ovarian disease. Serum and plasma samples were obtained preoperatively from 79 women undergoing surgery for pelvic mass; 48 of them had ovarian carcinoma, and 31 had benign cyst. The samples were analyzed for the levels of OPN and CA125 (using ELISA and CMIA methods) and then compared with the final pathologic results. The median plasma level of OPN in patients with benign and malignant cysts was 356.33 ng/ml and 865.15 ng/ml, respectively (p < 0.001). Receiver operating characteristic (ROC) analysis for plasma OPN revealed the area under the curve (AUC) of 0.838. At the predefined specificity of 90%, OPN showed sensitivity of 62.5%, whereas the combination of OPN + CA125 reached 74.9% at the same specificity.
Keywords
Ovarian cancer; Osteopontin; CA125; Tumor markers.
Cite and Share
M. Milivojevic,V. Boskovic,J. Atanackovic,S. Milicevic,S. Razic,B. Kastratovic Kotlica. Evaluation of osteopontin and CA125 in detection of epithelial ovarian carcinoma. European Journal of Gynaecological Oncology. 2013. 34(1);83-85.
References
[1] National Institutes of Health Consensus Development Conference Statement: “Ovarian cancer: screening, treatment and follow-up”. Gynecol. Oncol., 1994, 55, S4.
[2] Holschneider C.H., Berek J.S.: “Ovarian cancer. Epidemiology, biology and prognostic factors”. Semin. Surg. Oncol., 2000, 19, 3.
[3] Anborgh P.H., Mutrie J.C., Tuck A.B., Chambers A.F.: “Pre-and post-translational regulation of osteopontin in cancer”. J. Cell Commun. Signal., 2011, 5, 111.
[4] Nakae M., Iwamoto I., Fujino T., Maehata Y.,Togami Sh., Yoshinaga M., Douchi T.: “Preoperative plasma osteopontin level as a biomarker complementary to carbohydrate antigen CA125 in predicting ovarian cancer”. J. Obstet. Gynaecol. Res., 2006, 32, 309.
[5] Tiniakos D.G., Yu H., Liapis H.: “Osteopontin expression in ovarian carcinomas and tumors of low malignant potential (LMP)”. Hum. Pathol., 1998, 29, 1250.
[6] Ye B., Gagnon A., Mok S.C.: “Recent technical strategies to identify diagnostic biomarkers for ovarian cancer”. Expert. Rev. Proteomics, 2007, 4, 121.
[7] Langmar Z., Nemeth M., Vlesko G.,Kiraly M., Hornyak L., Bosze P.: “HE4-a novel promising serum marker in the diagnosis of ovarian carcinoma”. Eur. J. Gynaecol. Oncol., 2011, 32, 605.
[8] Hwang J., Na S., Lee H., Lee D.: “Correlation between preoperative serum levels of five biomarkers and relationships between these biomarkers and cancer stage in epithelial ovarian cancer”. J. Gynecol. Oncol., 2009, 20, 169.
[9] Kim K., Visinttin I., Alvero A. B., Mor G.: “Development and validation of a protein based signature for the detection of ovarian cancer”. Clin. Lab. Med., 2009, 29, 47.
[10] Moore R.G., Brown A.K., Miller M.C., Skates S., Allard W.J., Verch T. et al.: “The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass”. Gynecol. Oncol., 2008, 108, 402.
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