Condyloma acuminata induces focal intense FDG uptake mimicking vaginal stump recurrence from uterine cervical cancer: a case report

The 2-deoxy-2-[18F] fluoro-D-glucose position emission tomography/computed tomography (FDG PET/CT) findings of condyloma acuminata in a patient with FIGO Stage IB1 cervical cancer who had previously been treated with radical hysterectomy, pelvic chemoradiotherapy, and consolidation chemotherapy is described in this article. This case highlights the importance of considering condyloma acuminata during the differential diagnosis of abnormal vaginal FDG uptake in patients who have been treated for gynecological cancer.

FDG PET/CT; Condyloma acuminata; Cervical cancer; Recurrence.

[1] de la Fuente S.G., Ludwig K.A., Mantyh C.R.: “Preoperative immune status determines anal condyloma recurrence after surgical excision”. Dis. Colon Rectum., 2003, 46, 367.

[2] Mistrangelo M., Cornaglia S., Pizzio M., Rimonda R., Gavello G., Dal Conte I., Mussa A.: “Immunostimulation to reduce recurrence after surgery for anal condyloma acuminata: a prospective randomized controlled trial”. Colorectal Dis., 2010, 12, 799.

[3] De Panfilis G., Melzani G., Mori G., Ghidini A., Graifemberghi S.: “Relapses after treatment of external genital warts are more frequent in HIV-positive patients than in HIV-negative controls”. Sex Transm. Dis., 2002, 29, 121.

[4] Marshburn P.B., Trofatter K.F. Jr.: “Recurrent condyloma acuminatum in women over age 40: association with immunosuppression and malignant disease”. Am. J. Obstet. Gynecol., 1988, 159, 429.

[5] Insinga R.P., Dasbach E.J., Elbasha E.H.: “Epidemiologic natural history and clinical management of Human Papillomavirus (HPV) Disease: a critical and systematic review of the literature in the development of an HPV dynamic transmission model”. BMC Infect. Dis., 2009, 9, 119.

[6] Lowell D.M., LiVolsi V.A., Ludwig M.E.: “Genital condyloma virus infection following pelvic radiation therapy: report of seven cases”. Int. J. Gynecol. Pathol., 1983, 2, 294.

[7] Shokri-Tabibzadeh S., Koss L.G., Molnar J., Romney S.: “Association of human papillomavirus with neoplastic processes in the genital tract of four women with impaired immunity”. Gynecol. Oncol., 1981, 12, S129.

[8] Brooks R.A., Rader J.S., Dehdashti F., Mutch D.G., Powell M.A., Thaker P.H. et al.: “Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer”. Gynecol. Oncol., 2009, 112, 104.

[9] Liu F.Y., Yen T.C., Chen M.Y., Lai C.H., Chang T.C., Chou H.H. et al..: “Detection of hematogenous bone metastasis in cervical cancer: 18F-fluorodeoxyglucose-positron emission tomography versus computed tomography and magnetic resonance imaging”. Cancer, 2009, 115, 5470.

[10] Mabuchi S., Morimoto A., Fujita M., Isohashi K., Kimura T.: “G-CSF induces focal intense bone marrow FDG uptake mimicking multiple bone metastases from uterine cervical cancer: a case report and review of the literature”. Eur. J. Gynaecol. Oncol., 2012, 33, 316.