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Perivascular epithelial cell tumor arising from polypoid adenomyoma: a case report

  • T. Ishibashi1
  • K. Nakayama1,*,
  • N. Nakayama2
  • H. Katagiri1
  • N. Ishikawa3
  • K. Miyazaki1

1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo

2Department of Biochemistry, Shimane University School of Medicine, Izumo

3Department of Organ Pathology, Shimane University School of Medicine Izumo (Japan).

DOI: 10.12892/ejgo340122 Vol.34,Issue 1,January 2013 pp.104-106

Published: 10 January 2013

*Corresponding Author(s): K. Nakayama E-mail: kn88@med.shimane-u.ac.jp

Abstract

The present report describes a rare case of a uterine perivascular epithelioid cell tumor (PEComa) arising from a polypoid adenomyoma. The patient, a 44-year old woman with tuberous sclerosis, was incidentally found to have a uterine mass with malignantappearing features on a computed tomography (CT) scan. Pathological examination of the hysterectomy specimen demonstrated that the tumor was composed of pale, spindle-shaped, epithelioid tumor cells which were positive for SMA and HMB-45. These findings were consistent with a PEComa arising from a polypoid adenomyoma.

Keywords

Perivascular epithelioid cell tumor (PEComa); Uterus; Polypoid adenomyoma.

Cite and Share

T. Ishibashi,K. Nakayama,N. Nakayama,H. Katagiri,N. Ishikawa,K. Miyazaki. Perivascular epithelial cell tumor arising from polypoid adenomyoma: a case report. European Journal of Gynaecological Oncology. 2013. 34(1);104-106.

References

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[2] Froio E., Piana S., Cavazza A., Valli R., Abrate M., Gardini G.: “Multifocal PEComa (PEComatosis) of the female genital tract associated with endometriosis, diffuse adenomyosis, and endometrial atypical hyperplasia”. Int. J. Surg. Pathol., 2008, 16, 443.

[3] Yavuz E., Cakr C., Tuzlal S., Ahskal B., Topuz S., Ilhan R.: “Uterine perivascular epithelioid cell tumor coexisting with pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a case report”. Appl. Immunohistochem. Mol. Morphol., 2008, 16, 405.

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[5] Folpe A.L.: “Neoplasms with perivascular epithelioid cell differentiation (PEComas)”. In: Fletcher C.D.M., Unni K.K., Mertens F. (eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, IARC Press., 2002, 221.

[6] Folpe A.L., Mentzel T., Lehr H.A., Fisher C., Balzer B.L., Weiss S.W.: “Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature”. Am. J. Surg. Pathol., 2005, 29, 1558.

[7] Zamboni G., Pea M., Martignoni G., Zancanaro C., Faccioli G., Gilioli E. et al.: “Clear cell “sugar” tumor of the pancreas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells”. Am. J. Surg. Pathol., 1996, 20, 722.

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[10] Silverberg S.G.: “Adenomyomatosis of endometrium and endocervix-a hamartoma”. Am. J. Clin. Pathol., 1975, 64, 192.

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