Article Data

  • Views 386
  • Dowloads 148

Case Reports

Open Access

Perivascular epithelial cell tumor arising from polypoid adenomyoma: a case report

  • T. Ishibashi1
  • K. Nakayama1,*,
  • N. Nakayama2
  • H. Katagiri1
  • N. Ishikawa3
  • K. Miyazaki1

1Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo

2Department of Biochemistry, Shimane University School of Medicine, Izumo

3Department of Organ Pathology, Shimane University School of Medicine Izumo (Japan).

DOI: 10.12892/ejgo340122 Vol.34,Issue 1,January 2013 pp.104-106

Published: 10 January 2013

*Corresponding Author(s): K. Nakayama E-mail:


The present report describes a rare case of a uterine perivascular epithelioid cell tumor (PEComa) arising from a polypoid adenomyoma. The patient, a 44-year old woman with tuberous sclerosis, was incidentally found to have a uterine mass with malignantappearing features on a computed tomography (CT) scan. Pathological examination of the hysterectomy specimen demonstrated that the tumor was composed of pale, spindle-shaped, epithelioid tumor cells which were positive for SMA and HMB-45. These findings were consistent with a PEComa arising from a polypoid adenomyoma.


Perivascular epithelioid cell tumor (PEComa); Uterus; Polypoid adenomyoma.

Cite and Share

T. Ishibashi,K. Nakayama,N. Nakayama,H. Katagiri,N. Ishikawa,K. Miyazaki. Perivascular epithelial cell tumor arising from polypoid adenomyoma: a case report. European Journal of Gynaecological Oncology. 2013. 34(1);104-106.


[1] Fadare O.: “Uterine PEComa: appraisal of a controversial and increasingly reported mesenchymal neoplasm”. Int. Semin. Surg. Oncol., 2008, 5, 7.

[2] Froio E., Piana S., Cavazza A., Valli R., Abrate M., Gardini G.: “Multifocal PEComa (PEComatosis) of the female genital tract associated with endometriosis, diffuse adenomyosis, and endometrial atypical hyperplasia”. Int. J. Surg. Pathol., 2008, 16, 443.

[3] Yavuz E., Cakr C., Tuzlal S., Ahskal B., Topuz S., Ilhan R.: “Uterine perivascular epithelioid cell tumor coexisting with pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a case report”. Appl. Immunohistochem. Mol. Morphol., 2008, 16, 405.

[4] Yamagata Y., Kawauchi S., Tamura H., Murakami A., Sasaki K., Sugino N.: “A case of HMB45-negative perivascular epithelioid cell tumor (PEComa) of the uterine corpus: a possible diagnostic application of molecular-cytogenetic analysis”. Eur. J. Gynaecol. Oncol., 2009, 30, 216.

[5] Folpe A.L.: “Neoplasms with perivascular epithelioid cell differentiation (PEComas)”. In: Fletcher C.D.M., Unni K.K., Mertens F. (eds.). World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, IARC Press., 2002, 221.

[6] Folpe A.L., Mentzel T., Lehr H.A., Fisher C., Balzer B.L., Weiss S.W.: “Perivascular epithelioid cell neoplasms of soft tissue and gynecologic origin: a clinicopathologic study of 26 cases and review of the literature”. Am. J. Surg. Pathol., 2005, 29, 1558.

[7] Zamboni G., Pea M., Martignoni G., Zancanaro C., Faccioli G., Gilioli E. et al.: “Clear cell “sugar” tumor of the pancreas. A novel member of the family of lesions characterized by the presence of perivascular epithelioid cells”. Am. J. Surg. Pathol., 1996, 20, 722.

[8] Pea M., Martignoni G., Zamboni G., Bonetti F.: “Perivascular epithelioid cell”. Am. J. Surg. Pathol., 1996, 20, 1149.

[9] Lim G.S., Oliva E.: “The morphologic spectrum of uterine PECcell associated tumors in a patient with tuberous sclerosis”. Int. J. Gynecol. Pathol., 2011, 30, 121.

[10] Silverberg S.G.: “Adenomyomatosis of endometrium and endocervix-a hamartoma”. Am. J. Clin. Pathol., 1975, 64, 192.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Submission Turnaround Time