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Original Research

Open Access

The correlation between expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma

  • D. G. Hong1
  • N. Y. Park1
  • G. O. Chong1
  • Y. L. Cho1
  • I. S. Park1
  • M. J. Jeong2
  • J. Y. Park3
  • Y. S. Lee1,*,

1Gynecologic Cancer Center, Kyungpook National University Medical Center, Daegu

2Department of Mathematics, Korea Science Academy of Korea Advanced Institute of Science and Technology, Pusan

3Department of Pathology, Kyungpook National University Medical Center, Daegu (Republic of Korea)

DOI: 10.12892/ejgo340204 Vol.34,Issue 2,March 2013 pp.128-131

Published: 24 March 2013

*Corresponding Author(s): Y. S. Lee E-mail: yslee@knu.ac.kr

Abstract

Purpose: To evaluate the correlation between immunohistochemical expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma. Materials and Methods: A tissue microarray was constructed using formalinfixed, paraffin-embedded tissue that included 23 early and 18 advanced cases. The intensity and area of the immunohistochemical reactions were evaluated using the semi-quantitative scoring system. Results: Synuclein-γ expression was higher in the advanced stage, although it was not statistically significant (p = 0.51). Glucose transporter-1 was overexpressed in the advanced stage (p = 0.01). Synuclein-γ (score = 0 vs > 0) and glucose transporter-1 (score ≤ 7 vs > 7) did not show any differences in overall survival (p = 0.54, p = 0.48) and disease-free survival (p = 0.61, p = 0.14). Conclusion: In this study the expression of synuclein-γ and glucose transporter-1 were not considered to be a prognostic factor and were not related with survival outcomes in endometrioid endometrial carcinoma.

Keywords

Endometrial carcinoma; Synuclein-γ; Glucose transporter-1.

Cite and Share

D. G. Hong,N. Y. Park,G. O. Chong,Y. L. Cho,I. S. Park,M. J. Jeong,J. Y. Park,Y. S. Lee. The correlation between expression of synuclein-γ, glucose transporter-1, and survival outcomes in endometrioid endometrial carcinoma. European Journal of Gynaecological Oncology. 2013. 34(2);128-131.

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